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  4. AKAP4 Antibody

AKAP4 Antibody

  • 货号：
    CSB-PA425535
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA425535(AKAP4 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q5JQC9
  • 基因名：
    AKAP4
  • 别名：
    A kinase (PRKA) anchor protein 4 antibody; A kinase anchor protein 4 antibody; A kinase anchor protein 82 kDa antibody; A-kinase anchor protein 4 antibody; A-kinase anchor protein 82 kDa antibody; AKAP 4 antibody; AKAP 82 antibody; AKAP-4 antibody; AKAP4 antibody; AKAP4_HUMAN antibody; AKAP82 antibody; FSC 1 antibody; FSC1 antibody; hAKAP 82 antibody; hAKAP82 antibody; HI antibody; Major sperm fibrous sheath protein antibody; p82 antibody; PRKA 4 antibody; PRKA4 antibody; Protein kinase A anchoring protein 4 antibody; Protein kinase A-anchoring protein 4 antibody; Testis specific gene HI antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human AKAP4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Major structural component of sperm fibrous sheath. Plays a role in sperm motility.
  • 基因功能参考文献：
    1. High AKAP4 expression is associated with reduced sperm motility. PMID: 29581387
    2. A significant association was found between AKAP4 gene expression and metastasis (P-value: 0.045), expression of the CTAG1B (NY-ESO-1) gene was not observed in our cases. PMID: 29480665
    3. the physiological role of the negative crosstalk between the cAMP/PKA/AKAP4 and the PKC/ERK1/2 pathways is to regulate capacitation and acrosome reaction. PMID: 27901058
    4. AKAP4 role in the proliferation and metastasis of thyroid cancer.AKAP4 is highly expressed in thyroid cancer. PMID: 27983916
    5. AKAP4 appears to be a novel Colorectal cancer-associated antigen with a potential for developing as a new clinical therapeutic target PMID: 26590805
    6. AKAP4 is a highly accurate biomarker for the detection of early stage lung cancer. PMID: 26160834
    7. SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients. PMID: 25739119
    8. The putative role of AKAP4 in early tumorigenesis is implicated as a biomarker and immunotherapeutic target for cervical cancer. PMID: 23478221
    9. Ablation of AKAP4 protein caused significant inhibition in cellular proliferation, colony-forming ability, migration and invasion ability of tumor cells. PMID: 23764900
    10. data suggests that AKAP4 may be used as serum based diagnostic test for an early detection and diagnosis of breast cancer and may be a potential target for immunotherapeutic use PMID: 23451156
    11. We demonstrate the aberrant expression of AKAP-4 in prostate cancer, which will potentially be developed as a biomarker in prostate cancer. PMID: 21520158
    12. AKAP4 is a novel target for protein S-nitrosylation in spermatozoa. PMID: 17683036
    13. Role of AKAP4 in sperm motility is unclear, vut absent or weak AKAP4-labelling is associated with absent or weak sperm. motility. PMID: 17712481

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  • 亚细胞定位：
    Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum.
  • 蛋白家族：
    AKAP110 family
  • 组织特异性：
    Testis specific; only expressed in round spermatids.
  • 数据库链接：

    HGNC: 374

    OMIM: 300185

    KEGG: hsa:8852

    STRING: 9606.ENSP00000351327

    UniGene: Hs.97633