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  4. AKAP13 Antibody

AKAP13 Antibody

  • 货号：
    CSB-PA613265ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA613265ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA613265ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AKAP13 Polyclonal antibody
  • Uniprot No.：
    Q12802
  • 基因名：
  • 别名：
    A kinase (PRKA) anchor protein 13 antibody; A kinase anchor protein 13 antibody; A kinase anchoring protein antibody; A-kinase anchor protein 13 antibody; AKAP 13 antibody; AKAP Lbc antibody; AKAP-13 antibody; AKAP-Lbc antibody; AKAP13 antibody; AKP13_HUMAN antibody; ARHGEF13 antibody; Breast cancer nuclear receptor binding auxiliary protein antibody; Breast cancer nuclear receptor-binding auxiliary protein antibody; BRX antibody; c lbc antibody; FLJ11952 antibody; FLJ43341 antibody; Guanine nucleotide exchange factor Lbc antibody; HA 3 antibody; HA3 antibody; Ht 31 antibody; Ht31 antibody; Human thyroid anchoring protein 31 antibody; Human thyroid-anchoring protein 31 antibody; LBC antibody; LBC oncogene antibody; Lymphoid blast crisis oncogene antibody; Non oncogenic Rho GTPase specific GTP exchange factor antibody; Non-oncogenic Rho GTPase-specific GTP exchange factor antibody; p47 antibody; Protein kinase A anchoring protein 13 antibody; Protein kinase A-anchoring protein 13 antibody; PROTO LB antibody; PROTO LBC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human A-kinase anchor protein 13 protein (1-150AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1. Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3. Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy. Has no guanine nucleotide exchange activity on CDC42, Ras or Rac. Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes. Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol. Required for normal adaptive cardiac hypertrophy in response to pressure overload. Plays a role in osteogenesis.
  • 基因功能参考文献：
    1. We showed that AKAP13 is expressed in the alveolar epithelium and lymphoid follicles from patients with Idiopathic pulmonary fibrosis, and AKAP13 mRNA expression was 1.42-times higher in lung tissue from patients with Idiopathic pulmonary fibrosis than that in lung tissue from controls. PMID: 29066090
    2. AKAP-Lbc emerges as a coordinator of signals that protect cardiomyocytes against the toxic effects of DOX. PMID: 28923249
    3. evaluation of MAGT1 and AKAP13 expression in clinical hepatocellular carcinoma tissues by immunohistochemistry suggested that both proteins were strongly expressed in tumor tissues with significantly higher average immunoreactive scores of Remmele and Stegner (IRS) than in non-tumor tissues PMID: 26617690
    4. Studied molecular interactions involving anchoring protein AKAP13 in the process of PKA-induced tamoxifen resistance in breast cancer specimens and cell lines. PMID: 26272591
    5. Isothermal titration calorimetry showed that AKAP-Lbc has only micromolar affinity for RhoA, which combined with the presence of potential binding pockets for small molecules on AKAP-Lbc, raises the possibility of targeting AKAP-Lbc with GEF inhibitors. PMID: 25186459
    6. pleckstrin homology (PH) domain of Lbc is located at the C-terminal end of the protein and is shown here to specifically recognize activated RhoA rather than lipids PMID: 24993829
    7. activation of IKKbeta within the AKAP-Lbc complex promotes NF-kappaB-dependent production of interleukin-6 PMID: 23090968
    8. Shp2 is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart. PMID: 23045525
    9. Thus AKAP-Lbc may serve an ancillary cardioprotective role by favouring the association of PKA with Hsp20. PMID: 22731613
    10. Amplification of AKAP-13 is associated with metastatic and aggressive papillary thyroid carcinomas. PMID: 22161024
    11. One SNP (rs11638762), in the GATA-3 binding site upstream of the AKAP13 gene, was significantly replicated in another cohort for systolic blood pressure PMID: 21228793
    12. A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation. PMID: 21224381
    13. third new locus (rs6496932), on 15q25.3 (beta = 0.13, P = 1.4 x 10(-8)), was within a wide linkage disequilibrium block extending into the 5' end of the AKAP13 gene, encoding a scaffold protein concerned with signal transduction from the cell surface PMID: 20719862
    14. Study demonstrates that the A-kinase-anchoring protein AKAP-Lbc and the scaffolding protein kinase suppressor of Ras (KSR-1) form the core of a signalling network that efficiently relay signals from RAF, through MEK, and on to ERK1/2. PMID: 21102438
    15. the Lbc/alpha-catulin axis participates in 5-HT-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling. PMID: 20696764
    16. The positive expression rate of AKAP13 protein in colorectal carcinoma (52.3%) was significantly higher than those in adenoma (9.1%) and normal tissue (34.7%) (P = 0.006) by immunohistochemical staining. PMID: 19779964
    17. backbone and side chain (1)H, (13)C and (15)N resonance assignments of a 20 kDa construct comprising the uniformly (13)C and( 15)N labeled AKAP13-PH domain and an associated helix from the DH domain which is required for its stable expression PMID: 19888694
    18. Results show that alpha-catulin co-expression leads to increased Lbc-induced serum response factor activation and may modulate Rho pathway signaling in vivo by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor. PMID: 12270917
    19. The HA-3 peptide, VTEPGTAQY, is encoded by the lymphoid blast crisis oncogene, showing for the 1st time that a leukemia-associated oncogene can give rise to immunogenic T-cell epitopes that may participate in antihost & antileukemic alloimmune responses. PMID: 12663445
    20. Proto-Lbc mutant expression led to decreased levels of Galpha12-induced RhoA activation in vivo. PMID: 14636890
    21. results indicate that guanine nucleotide exchange factor Lbc is a novel signal transducer for RhoA-mediated NF-kappaB activation in human peripheral blood monocytes stimulated with bacterial products PMID: 14660653
    22. Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex. PMID: 15229649
    23. Rho-GEF activity of AKAP-Lbc is mediated by leucine zipper-mediated homo-oligomerization regulates PMID: 15691829
    24. significant association seen between rare AKAP13 Lys526Glyn variant and increased risk of development breast cancer; this variant might affect susceptibility to other cancers and might influence response to anticancer drugs targeting rho proteins PMID: 16234258
    25. Yeast 2-Hybrid experiments identified a strong and novel interaction between the transglutaminase moiety and protein kinase A anchor protein 13 (AKAP13) PMID: 16301118
    26. The spatiotemporal expression of Brx was altered in eutopic endometrium of women with endometriosis. PMID: 16412732
    27. Brx modifies the actions of glucocorticoids, enhancing the transcriptional activity of glucocorticoid receptor (GR) by interacting with GR and by attracting Rho family G proteins to the GR-induced transcriptisome PMID: 16469733
    28. AKAP13 plays a role in TLR2-mediated NF-kappaB activation; GEF-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs PMID: 17878165
    29. findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation PMID: 18445682
    30. Data suggest that LC3 binding maintains AKAP-Lbc in an inactive state that displays a reduced ability to promote downstream signaling. PMID: 19696020

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm. Cytoplasm, cell cortex. Nucleus. Membrane; Peripheral membrane protein.
  • 组织特异性：
    Detected in mammary gland. Detected in heart (at protein level). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and
  • 数据库链接：

    HGNC: 371

    OMIM: 604686

    KEGG: hsa:11214

    STRING: 9606.ENSP00000354718

    UniGene: Hs.459211