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AKAP11 Antibody

  • 货号：
    CSB-PA006794
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKA4
  • 基因名：
  • 别名：
    AKAP11 antibody; AKAP220 antibody; KIAA0629 antibody; A-kinase anchor protein 11 antibody; AKAP-11 antibody; A-kinase anchor protein 220 kDa antibody; AKAP 220 antibody; hAKAP220 antibody; Protein kinase A-anchoring protein 11 antibody; PRKA11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human AKAP 220.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
  • 基因功能参考文献：
    1. PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. PMID: 25188285
    2. Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3beta to A-kinase Anchoring Protein 220. PMID: 26088133
    3. AKAP220 protein organizes signaling elements that impact cell migration. PMID: 21890631
    4. binds to glycogen synthase kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent inhibition of GSK-3beta PMID: 12147701
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
  • 蛋白家族：
    AKAP110 family
  • 组织特异性：
    Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.
  • 数据库链接：

    HGNC: 369

    OMIM: 604696

    KEGG: hsa:11215

    STRING: 9606.ENSP00000025301

    UniGene: Hs.105105