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AHSA1 Antibody

  • 货号：
    CSB-PA05455A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: AHSA1 antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 39, 33 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA05455A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AHSA1 Polyclonal antibody
  • Uniprot No.：
    O95433
  • 基因名：
    AHSA1
  • 别名：
    Activator of 90 kDa heat shock protein ATPase homolog 1 antibody; Activator of heat shock 90kDa protein ATPase homolog 1 antibody; AHA 1 antibody; AHA1 antibody; AHSA 1 antibody; Ahsa1 antibody; AHSA1_HUMAN antibody; C14orf3 antibody; HSPC322 antibody; p38 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Activator of 90 kDa heat shock protein ATPase homolog 1 protein (1-338AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AHSA1 Antibody (CSB-PA05455A0Rb)，的标记方式是Non-conjugated。对于AHSA1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA05455B0Rb AHSA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA05455C0Rb AHSA1 Antibody, FITC conjugated
    Biotin CSB-PA05455D0Rb AHSA1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.
  • 基因功能参考文献：
    1. Aha1 colocalized with tau pathology in brain tissue, and this association positively correlated with Alzheimer disease progression. PMID: 28827321
    2. These results suggest that differences in the middle domain of Hsp90alpha and Hsp90beta may be responsible for the isoform-specific interactions with selected proteins. PMID: 25486457
    3. Aha1 may promote disposal of folding defective proteins by the cellular protein quality control. PMID: 25378400
    4. a monoallelic mutation of p53 was sufficient to activate the Aha1/Hsp90 ATPase axis leading to stimulation of Wnt signaling and increased expression of Wnt target genes. PMID: 24451373
    5. Modulation of Hsp90 activity by AHA1 regulates VEGF signaling to eNOS and angiogenesis. PMID: 22859491
    6. The interaction of Aha1 with Hsp90 and its co-chaperones in rabbit reticulocyte lysate (RRL) and in HeLa cell extracts, was characterized. PMID: 22504172
    7. Hsp90 phosphorylation on tyrosine313 promotes recruitment of AHA1, which stimulates Hsp90 ATPase activity, furthering the chaperoning process. PMID: 22727666
    8. Data propose a model for Aha1 in the Hsp90 ATPase cycle where Aha1 regulates dwell time of Hsp90, and suggest Aha1 activity integrates chaperone function with client folding energetics by modulating ATPase sensitive dimer structural transitions. PMID: 20089831
    9. stimulates the inherent ATPase activity of Hsp90 PMID: 12504007
    10. Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum PMID: 17110338

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  • 亚细胞定位：
    Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.
  • 蛋白家族：
    AHA1 family
  • 组织特异性：
    Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
  • 数据库链接：

    HGNC: 1189

    OMIM: 608466

    KEGG: hsa:10598

    STRING: 9606.ENSP00000216479

    UniGene: Hs.204041