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AGTRAP Antibody

  • 货号：
    CSB-PA964373
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA964373(AGTRAP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA964373(AGTRAP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q6RW13
  • 基因名：
    AGTRAP
  • 别名：
    AGTRAP; ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human AGTRAP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
  • 基因功能参考文献：
    1. A role for AT1 receptor-associated proteins in blood pressure regulation PMID: 25562590
    2. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function. PMID: 23902639
    3. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein). PMID: 21728994
    4. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock. PMID: 21423001
    5. CSF angiotensin II, ACE, and ACE2 levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 antibody, reflecting severe destruction of perivascular astrocytes PMID: 20541774
    6. Endogenous increases in angiotensin II during dehydration contribute to dehydration-associated sympathoexcitation. PMID: 19805740
    7. Small interfering RNA significantly attenuates angiotensin II type 1 receptor-stimulated inositol phosphate formation. PMID: 20018811
    8. cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein PMID: 11733189
    9. isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK-293 cells PMID: 14559250
    10. mRNA is detected in all human tissues; cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells. PMID: 14985364
    11. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
  • 组织特异性：
    Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
  • 数据库链接：

    HGNC: 13539

    OMIM: 608729

    KEGG: hsa:57085

    STRING: 9606.ENSP00000319713

    UniGene: Hs.464438