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AGBL5 Antibody

  • 货号：
    CSB-PA074141
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA074141(AGBL5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA074141(AGBL5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8NDL9
  • 基因名：
    AGBL5
  • 别名：
    AGBL5 antibody; ATP/GTP binding protein like 5 antibody; ATP/GTP-binding protein-like 5 antibody; CBPC5_HUMAN antibody; CCP5 antibody; Cytosolic carboxypeptidase like protein 5 antibody; Cytosolic carboxypeptidase-like protein 5 antibody; FLJ21839 antibody; Hypothetical protein FLJ21839 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human AGBL5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.
  • 基因功能参考文献：
    1. Homology models indicated destabilization of AGBL5 due to the p.Arg281Cys change. PMID: 27764769
    2. The identification of AGBL5 and TTLL5, a previously described RP-associated gene encoding the tubulin tyrosine ligase-like family, member 5 protein, highlights the importance of poly- and deglutamylation in retinal homeostasis. PMID: 27842159
    3. Due to the characteristic Retinitis Pigmentosa phenotype in patients carrying the AGBL5 missense mutation we suggest this gene as a candidate for a new form of autosomal recessively inherited RP PMID: 26720455
  • 相关疾病：
    Retinitis pigmentosa 75 (RP75)
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
  • 蛋白家族：
    Peptidase M14 family
  • 组织特异性：
    Expressed in brain.
  • 数据库链接：

    HGNC: 26147

    OMIM: 615900

    KEGG: hsa:60509

    STRING: 9606.ENSP00000353249

    UniGene: Hs.138207