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AEN Antibody

  • 货号：
    CSB-PA819883LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA819883LA01HU at 1:530, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) AEN Polyclonal antibody
  • Uniprot No.：
    Q8WTP8
  • 基因名：
    AEN
  • 别名：
    Aen antibody; AEN_HUMAN antibody; apoptosis enhancing nuclease antibody; Apoptosis-enhancing nuclease antibody; Interferon stimulated exonuclease gene 20kDa like 1 antibody; Interferon stimulated exonuclease gene 20kDa like 1; isoform CRA_a antibody; Interferon-stimulated 20 kDa exonuclease-like 1 antibody; ISG20L1 antibody; pp12744 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Apoptosis-enhancing nuclease protein (117-325AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，AEN Antibody (CSB-PA819883LA01HU)，的标记方式是Non-conjugated。对于AEN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA819883LB01HU AEN Antibody, HRP conjugated ELISA
    FITC CSB-PA819883LC01HU AEN Antibody, FITC conjugated
    Biotin CSB-PA819883LD01HU AEN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
  • 基因功能参考文献：
    1. identification of ISG20L1 as a p53 family target and discovery that modulation of this target can regulate autophagic processes further strengthens the connection between p53 signaling and autophagy PMID: 20429933
    2. AEN is an important downstream mediator of p53 in apoptosis induction in cancer. PMID: 18264133
  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
  • 数据库链接：

    HGNC: 25722

    OMIM: 610177

    KEGG: hsa:64782

    STRING: 9606.ENSP00000331944

    UniGene: Hs.436102