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ADRA2C Antibody

  • 货号：
    CSB-PA041229
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HepG2 cells, using Adrenergic Receptor α-2C antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADRA2C Polyclonal antibody
  • Uniprot No.：
    P18825
  • 基因名：
  • 别名：
    ADRA2C; ADRA2L2; ADRA2RL2; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2CAR
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human Adrenergic Receptor α-2C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
  • 基因功能参考文献：
    1. The frequency of alpha2CDel322-325-AR in suicide and non-suicide victims was similar. Genotype frequencies for the alpha2CDel322-325-AR polymorphism in depressed and schizophrenic subjects were higher than in controls, but these differences did not reach statistical significance. The results indicate that alpha2CDel322-325-AR may play a role in the pathophysiology of opiate abuse and dependence. PMID: 27007576
    2. Immunoreactivity for ADRA2C was densely distributed in vascular smooth muscle of nasal turbinates. PMID: 26739946
    3. ADRA2c is associated with heart rate recovery after exercise. PMID: 26058836
    4. Common polymorphisms in the ADRA2C gene are not associated with orthostatic hypotension risk in Chinese. PMID: 26427149
    5. Adrenergic receptor genotype influences heart failure severity and beta-blocker response in children with dilated cardiomyopathy. PMID: 25406899
    6. alpha2C-adrenoreceptor interaction with filamin-2 PMID: 25110951
    7. Genetic variants of ADRA2C do not alter intracellular localization or plasma membrane trafficking. PMID: 24643471
    8. the ADRA2C 322-325I/D genotype is a novel genetic risk marker for SBI among individuals with hyperhomocysteinemia. PMID: 24676565
    9. the region comprising the N-terminal half of The receptors contributed to the alpha2C-selectivity of drug binding. PMID: 23868076
    10. Bucindolol prevents ventricular arrhythmias in subjects with heart failure and reduced left ventricular ejection fractions, and this effect is modulated by adrenergic alpha 2 receptor polymorphisms. PMID: 23275278
    11. the predicted signal peptide in the N-terminal tail of the alpha(2C)-adrenoceptor does not act as a cleavable signal peptide PMID: 22503931
    12. there is little evidence for an association between alpha(2C)Del322-325 polymorphism and an increased prevalence of left ventricular hypertrophy in patients with systemic hypertension. PMID: 22040172
    13. Genotype polymorphism frequencies for B1 receptor (amino acid positions 389 and 49) and alpha 2c receptor (deletion 322-325) are not significantly different in SC patients compared to female controls. PMID: 19167638
    14. The alpha(2C)-Del322-325 polymorphism does not exhibit reduced signalling to adenylyl cyclase and may not represent a clinically important phenotype. PMID: 20128806
    15. The common ADRA2C variant affected pain perception before and after dexmedetomidine but did not affect other cognitive responses PMID: 19423370
    16. the norepinephrine lowering and clinical therapeutic responses to bucindolol were strongly influenced by alpha(2C) receptor genotype PMID: 19880803
    17. Increased expression of alpha(2C)-adrenoceptors may contribute to enhanced cold-induced vasoconstriction and Raynaud's phenomenon. PMID: 15345481
    18. ADRA2C had one haplotype block of 10 kb PMID: 15592690
    19. alpha2CDel322-325 polymorphism is associated with increased sympathetic nervous and adrenomedullary hormonal activities, both during supine rest and during pharmacologically evoked catecholamine release PMID: 15861038
    20. A genetic variant of the alpha 2C-adrenoceptor subtype--resulting from the deletion of four consecutive amino acids at codons 322-325--confers a change in brain function playing a role in the pathogenesis of major depressive disorder. PMID: 16407897
    21. Genetic variations of the alpha and beta adrenergic receptors (alpha 2C Del322-325 allele) were found to be significant predictors of vasospastic angina PMID: 16569551
    22. alpha(2)-ARs might contribute neurotrophic actions in vivo synergistically or in permutation with other neurotrophic factors PMID: 17192578
    23. The ADRA2C deletion polymorphism had no effect on markers of resting sympathetic activity and cardiovascular measures, and did not account for ethnic differences in blood pressure. PMID: 17351367
    24. An estrogen-dependent increase in expression of cold-sensitive alpha(2C)-ARs may contribute to the increased activity of cold-induced vasoconstriction under estrogen-replete conditions PMID: 17644575
    25. Homozygosity for the alpha 2C Del322-325 polymorphism is not associated with heart failure in black South Africans PMID: 18320080
    26. Because the alpha(2C)-adrenoceptor distribution pattern is conserved between rodents and humans, studies on the role of the alpha(2C)-adrenoceptor in rodent models of neuropsychiatric disorders may be relevant also for human diseases. PMID: 18435421
    27. Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors. PMID: 18487435
    28. Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses PMID: 18698227
    29. Genotype and haplotype of ADRA2C did not significantly affect survival in metoprolol-treated or carvedilol-treated heart failure patients. PMID: 18702968
    30. Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry. PMID: 18776959
    31. Our findings provide important evidence that the ADRA2C polymorphism is involved in the etiology of ADHD in Korean subjects. PMID: 18835330
    32. Three polymorphisms in ADRA2C and five polymorphisms in ADRB1 were involved in eight cross-validated epistatic interactions identifying several two-locus genotype classes with significant relative risks of death/transplant in heart failure patients PMID: 18947427
    33. The ADRA2C del322-325 variant did not affect vascular sensitivity to local cold exposure. PMID: 19444546

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2C sub-subfamily
  • 数据库链接：

    HGNC: 283

    OMIM: 104250

    KEGG: hsa:152

    STRING: 9606.ENSP00000386069

    UniGene: Hs.123022