Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ADNP Antibody

ADNP Antibody

  • 货号：
    CSB-PA887964HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA887964HA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Western Blot
      Positive WB detected in: U251 whole cell lysate, HL60 whole cell lysate, 293T whole cell lysate
      All lanes: ADNP antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 124 kDa
      Observed band size: 135 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADNP Polyclonal antibody
  • Uniprot No.：
    Q9H2P0
  • 基因名：
  • 别名：
    Activity dependent neuroprotective protein antibody; Activity dependent neuroprotector antibody; Activity-dependent neuroprotective protein antibody; Activity-dependent neuroprotector homeobox protein antibody; Adnp antibody; ADNP_HUMAN antibody; KIAA0784 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Activity-dependent neuroprotector homeobox protein (867-1102AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ADNP Antibody (CSB-PA887964HA01HU)，的标记方式是Non-conjugated。对于ADNP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887964HB01HU ADNP Antibody, HRP conjugated ELISA
    FITC CSB-PA887964HC01HU ADNP Antibody, FITC conjugated
    Biotin CSB-PA887964HD01HU ADNP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
  • 基因功能参考文献：
    1. in patients with intellectual disability, autism spectrum disorder and features suggestive of Noonan syndrome should have DNA analysis for the ADNP gene if the Noonan syndrome panel failed to identify a specific mutation. PMID: 29424797
    2. The role of ADNP in autophagy, and in autism, schizophrenia and Alzheimer's disease is described. PMID: 28940660
    3. Our findings indicate that ADNP is a tumor suppressor and promising prognostic marker, and that ketamine treatment with ADNP induction is a potential therapeutic approach that may add benefit to current treatment protocols for patients with colorectal cancer PMID: 27903678
    4. From a clinical standpoint, a differential diagnosis of patients with blepharophimosis should include ADNP mutations in addition to blepharophimosis ptosis epicanthus inversus syndrome, especially when intellectual disability is present PMID: 28407407
    5. The parents of 44/54 ADNP-mutated children reported an almost full erupted dentition by 1 year of age, including molars and only 10 of the children had teeth within the normal developmental time range. PMID: 28221363
    6. SHANK3, CHD8, and ADNP had distinctly higher scores than all other genes in the dataset describing the genes associated with autism spectrum disorders. PMID: 27790361
    7. The study identified intratumoral heterogeneity (ITH) of the ADNP mutations in colorectal cancers, suggesting that ADNP mutations occurred during tumor progression rather than as an early event. The generation of ITH may influence on clinical outcome of the cancer patients. PMID: 27308845
    8. These findings demonstrate that the down-regulation of protein ADNP is an early pathological alteration and may contribute to dopaminergic neurodegeneration in Parkinson's disease PMID: 27003787
    9. This review covers the myriad of important ADNP-protein interactions and glimpse at their potential meaning in autism, schizophrenia and Alzheimer's disease. [review] PMID: 25955282
    10. ADNP expression was increased in male hippocampus samples compared to female samples. PMID: 25646590
    11. Mutations in the ADNP gene cause syndromic autism.Ample evidence exists that ADNP is of key importance for proper functioning of the nBAF complex. PMID: 25169753
    12. This study showed ADNP that deregulated in postmortem hippocampal samples from schizophrenia patients, but that now showed a significantly increased expression in lymphocytes from related patients. PMID: 24365867
    13. Ten patients with autism spectrum disorders and other shared clinical characteristics, including intellectual disability and facial dysmorphisms caused by a mutation in ADNP, a transcription factor involved in the SWI/SNF remodeling complex. PMID: 24531329
    14. Chromatin immunoprecipitation demonstrates the ability of ADNP to bind to its own promoter, consistent with its action as a repressor of both promoter-supported and endogenous ADNP expression. PMID: 21647709
    15. Our results suggested that ADNP may play an important role in slowing the progression of clinical symptoms of AD. PMID: 22554909
    16. ADNP is expressed in many immune system cells. ADNP mRNA is reduced in PBMCs in MS. The peptide NAP, which plays an important role in neuroprotection, has potential immunomodulatory properties. PMID: 19923857
    17. Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. PMID: 17878164

    显示更多

    收起更多

  • 相关疾病：
    Helsmoortel-van der Aa syndrome (HVDAS)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissue
  • 数据库链接：

    HGNC: 15766

    OMIM: 611386

    KEGG: hsa:23394

    STRING: 9606.ENSP00000342905

    UniGene: Hs.293736