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ADM Antibody

  • 货号：
    CSB-PA988424
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA988424(ADM Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA988424(ADM Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P35318
  • 基因名：
    ADM
  • 别名：
    Adm antibody; ADM precursor antibody; ADML_HUMAN antibody; Adrenomedullin antibody; AM antibody; PAMP antibody; Preproadrenomedullin antibody; Proadrenomedullin N-20 terminal peptide antibody; Proadrenomedullin N20 terminal peptide antibody; ProAM N terminal 20 peptide antibody; ProAM N-terminal 20 peptide antibody; ProAM N20 antibody; ProAM-N20 antibody; ProAMN20 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ADM
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
  • 基因功能参考文献：
    1. Up-regulated mRNA and protein levels of proadrenomedullin (ProADM) during acute myocardial infarction in mice and humans. PMID: 30166452
    2. ADM was an upstream molecule of HIF-1alpha/VEGF and it promoted angiogenesis through upregulating HIF-1alpha/VEGF in epithelial ovarian cancer. PMID: 28091613
    3. Identifying a marker(adrenomedullin) for pancreatic cancer among high-risk patients such as new-onset diabetics might lead to the identification of a subpopulation needing to be screened in order to enable early diagnosis and treatment of a highly lethal tumor PMID: 29192743
    4. High ADM expression is associated with lymph node metastasis in oral and oropharyngeal squamous cell carcinoma. PMID: 29590186
    5. High expression of ADM is correlated with sunitinib-resistant renal cell carcinoma. PMID: 27556517
    6. results indicate a novel function of adrenomedullin (ADM) in pancreatic ductal adenocarcinoma (PDAC), and suggest ADM is a promising target in the treatment of PDAC. PMID: 27391260
    7. Report an association of elevated ProADM blood levels and 10-year all-cause mortality in a primary care cohort with respiratory tract infections. PMID: 28676115
    8. These results indicate that elevated ADM may be involved in the etiology of schizophrenia through the regulation of heat shock protein signaling. PMID: 27776076
    9. our results pointed towards two MR-pro-ADM threshold values that appear to predict with a good degree of accuracy the patient's need for non-invasive mechanical ventilation, endotracheal intubation, or intensive care. This aspect, however, deserves further investigation PMID: 29161297
    10. promotes the proliferation and inhibits apoptosis of dental pulp stem cells PMID: 27475098
    11. MR-proADM but not copeptin was significantly associated with prognosis of COPD exacerbations at 30 days. PMID: 28408815
    12. Findings indicate the importance of cancer-associated fibroblasts (CAFs)-derived adrenomedullin (AM) pathway in growth of breast carcinoma and in neovascularization by supplying and amplifying signals that are essential for pathologic angiogenesis. PMID: 28178651
    13. This study indicates that in children with community-acquired pneumonia, sTREM-1, Midregional-proANP, and Midregional-proADM blood levels have poor abilities to differentiate bacterial from viral diseases or to identify severe cases. PMID: 27846213
    14. Admission MR-proADM concentrations provide strong prognostic information in patients with acute HF, but modest diagnostic information in patients with acute dyspnea. PMID: 28065681
    15. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
    16. SHH acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells . PMID: 27246849
    17. MR-proADM showed a significant association with BP reduction after 6 months PMID: 27153479
    18. Elevated plasma level of MR-proADM, determined 24 h after diagnosis of Cardiogenic shock could be a predictor of in-hospital mortality in patients with acute myocardial infarction complicated by CS. PMID: 27788594
    19. Our findings showed that adrenomedullin expression increased in progression from benign endometrium to endometrial intraepithelial neoplasia and type-1 adenocarcinoma PMID: 26972419
    20. The levels of IL-8, IL-12, and adrenomedullin may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF. PMID: 27491770
    21. Evidence show that ADM could affect the growth and differentiation of leukemia cells by modulating RAMPs/CRLR expression, PI3K/Akt cascade and the ERK/MAPK signaling pathway. PMID: 26847772
    22. A panel of three biomarkers (MR-proANP, PCT, and MR-proADM) in patients presenting to the emergency unit with acute dyspnea provides information about the probability of acute heart failure, nonsurvival, and pneumonia. PMID: 26748496
    23. Higher levels of Proadrenomedullin are associated with Primary Graft Dysfunction and Mortality Following Lung Transplantation. PMID: 26461449
    24. conclusion supplementation with selenium and coenzyme Q10 during four years resulted in less concentration of both copeptin and MR-proADM PMID: 26662217
    25. High Adrenomedullin expression is associated with Malignant Pleural Mesothelioma. PMID: 26762744
    26. Among adrenomedullin, CRP, and PCT, procalcitonin demonstrates the highest correlation with the severity of infection. PMID: 26271020
    27. we found significantly lower plasma MR-proADM levels in patients with elevated anxiety scores PMID: 26342564
    28. AM is expressed by peritoneal mesothelial cells and actively amidated in the abdominal cavity of patients undergoing peritoneal dialysis. PMID: 23564381
    29. Results suggest that ADM plays an important role in intrahepatic cholangiocellular carcinoma metastasis, and that ADM signaling of epithelial-mesenchymal transition may represent a valuable therapeutic target in cancer patients. PMID: 26043778
    30. targeting of the ADM/ADM acceptors/ERK1/2/Bcl-2 pathway may provide a potential strategy through which to induce the apoptosis of osteosarcoma cells. PMID: 26035796
    31. In addition to its role in the complement system, complement factor H has an another role, as a binding protein for the regulatory peptide adrenomedullin. (Review) PMID: 26597206
    32. Proadrenomedullin was increased in complicated vs. uncomplicated community acquired pediatric pneumonia. PMID: 26286191
    33. AM expression gets rapidly activated by hypoxia through a HIF-1alpha mediated mechanism, thus characterizing AM as a major survival factor for tumour cells PMID: 25475159
    34. tested the hypothesis that AM-deficient fetal primary pulmonary microvascular endothelial cells (HPMEC) will have increased oxidative stress, inflammation, and cytotoxicity compared to AM-sufficient HPMEC upon exposure to hyperoxia PMID: 26196743
    35. Diabetes status had no impact on midregional proadrenomedullin concentrations or in the predictive value of heart failure. PMID: 25528198
    36. Allelic variation in ADM and increased plasma MR-proADM are associated with susceptibility to progression of diabetic kidney disease in type 2 diabetic patients. PMID: 25948679
    37. Adrenomedullin potentiates osteolytic responses in bone to metastatic breast cancer cells. PMID: 25439669
    38. Plasma adrenomedullin level is enhanced in nasopharyngeal carcinoma.Adrenomedullin is correlated with stage progression and with long-term survival of nasopharyngeal carcinoma patients. PMID: 25433141
    39. There was a significant increase in plasma AM, VCAM-1, and ICAM-1, while a significant decrease in plasma basic-Fibroblast growth factor (b-FGF) in diabetic patients with peripheral vascular disease (p < 0.05). PMID: 25287126
    40. the ADM gene has a role in the modulation of peripheral vascular tone PMID: 25053723
    41. plasma mid-regional pro-adrenomedullin helps predict pre-eclampsia PMID: 24853905
    42. ADM genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood. PMID: 25313554
    43. higher plasma adrenomedullin levels on presentation are associated with clinical severity and worse outcomes in patients with acute spontaneous aneurysmal subarachnoid hemorrhage PMID: 25009125
    44. midregional pro-adrenomedullin plasma concentrations blunted in severe preeclampsia PMID: 25043691
    45. adrenomedullin acts as a critical promoter of cell cycle progression in hepatocellular carcinoma cells PMID: 24927229
    46. Elevated plasma adrenomedullin concentration is highly associated with 3-month clinical outcomes and early neurological deterioration of patients with acute intracerebral hemorrhage. PMID: 24457114
    47. Results demonstrate a novel function of HIFs in regulating ADM expression by enhancing its pre-mRNA splicing. PMID: 24523299
    48. N-terminal PEGylated Adrenomedullin stimulated cAMP production in vitro, showing lessened acute hypotensive action and a prolonged plasma half-life in comparison with native Adrenomedullin peptide in vivo. PMID: 24874704
    49. the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus PMID: 24831942
    50. The correlation of ADM expression level with the measures of stroke severity implicates ADM -a potential blood bio-marker in studies of ischemic stroke. PMID: 23968191

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Adrenomedullin family
  • 组织特异性：
    Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
  • 数据库链接：

    HGNC: 259

    OMIM: 103275

    KEGG: hsa:133

    STRING: 9606.ENSP00000278175

    UniGene: Hs.441047