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ADI1 Antibody

  • 货号：
    CSB-PA781963
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q9BV57
  • 基因名：
    ADI1
  • 别名：
    1 2 dihydroxy 3 keto 5 methylthiopentene dioxygenase antibody; 1 antibody; 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase antibody; Aci reductone dioxygenase antibody; Acireductone dioxygenase (Fe(2+) requiring) antibody; Acireductone dioxygenase (Ni(2+) requiring) antibody; Acireductone dioxygenase (Ni(2+)-requiring) antibody; Acireductone dioxygenase 1 antibody; ADI 1 antibody; Adi1 antibody; ADI1 antibody antibody; APL1 antibody; ARD antibody; EC 1.13. antibody; Fe ARD antibody; FLJ10913 antibody; HMFT1638 antibody; Membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1 antibody; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1 antibody; MT1 MMP cytoplasmic tail binding protein 1 antibody; MTCBP 1 antibody; MTCBP-1 antibody; MTCBP1 antibody; MTND_HUMAN antibody; Ni-ARD antibody; SIPL antibody; Submergence induced protein 2 antibody; Submergence induced protein 2 homolog antibody; Submergence induced protein like factor antibody; Submergence-induced protein 2 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 71-120
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
  • 基因功能参考文献：
    1. High ADI1 expression is associated with malignant glioma. PMID: 30066900
    2. The thermal stability of the HsARD isozymes is a function of the metal ion identity, with Ni2+-bound HsARD being the most stable followed by Co2+ and Fe2+, and Mn2+-bound HsARD being the least stable. PMID: 28062648
    3. In summary, clinical and cell-based experiments suggested that physical interaction between MT1-MMP and ADI1 led to suppression of hepatitis C virus infection. This inhibitory effect could be reversed by ADI1 overexpression. PMID: 26537061
    4. Data elucidate a new role for MTCBP-1 regulating the intracellular function of MT1-MMP-mediated autophagy. Their inverse expression correlation with brain tumor grades could also contribute to the decreased autophagic index observed in high-grade tumors. PMID: 25640948
    5. MTCBP-1 is a new member of the Cupin superfamily with a role as an invasion suppressor down-regulated in tumors PMID: 14718544
    6. nucleo-cytoplasmic transport of hADI1 is regulated by a non-canonical nuclear export signal (NES) located in the N-terminal region of hADI1. PMID: 17212658
    7. ADI1 may check prostate cancer progression through apoptosis by an activity that does not require metal binding. PMID: 17786183
    8. 293-ADI1-CD81 cells are permissive for serum-derived HCV infection. PMID: 19626614

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
  • 蛋白家族：
    Acireductone dioxygenase (ARD) family
  • 组织特异性：
    Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
  • 数据库链接：

    HGNC: 30576

    OMIM: 613400

    KEGG: hsa:55256

    STRING: 9606.ENSP00000333666

    UniGene: Hs.502773