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ADCY3 Antibody

  • 货号：
    CSB-PA241921
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA241921(ADCY3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA241921(ADCY3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, human fetal brain tissue, Primary antibody: CSB-PA241921(ADCY3 Antibody) at dilution 1/312.5, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

产品详情

  • Uniprot No.：
    O60266
  • 基因名：
  • 别名：
    AC-III antibody; AC3 antibody; ADCY3 antibody; ADCY3_HUMAN antibody; adenylate cyclase 3 antibody; Adenylate cyclase antibody; Adenylate cyclase type 3 antibody; Adenylate cyclase type III antibody; Adenylyl cyclase 3 antibody; ATP pyrophosphate lyase antibody; ATP pyrophosphate-lyase 3 antibody; olfactive type antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ADCY3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
  • 基因功能参考文献：
    1. This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. PMID: 29921800
    2. In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops. PMID: 28122017
    3. Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase PMID: 25431134
    4. The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. PMID: 25044758
    5. Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism. PMID: 24113161
    6. endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3 PMID: 22681560
    7. Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons. PMID: 23077041
    8. This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder. PMID: 21042317
    9. Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. PMID: 21079816
    10. identified AC3as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation PMID: 12623444
    11. expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules PMID: 12782409
    12. Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade. PMID: 17581954
    13. This the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes. PMID: 17895882
    14. These results suggest that the length of primary cilia is controlled, at least in part, by the adenylate cyclase III-cAMP signaling pathway. PMID: 19576885

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 组织特异性：
    Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis.
  • 数据库链接：

    HGNC: 234

    OMIM: 600291

    KEGG: hsa:109

    STRING: 9606.ENSP00000260600

    UniGene: Hs.467898