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ADAMTS6 Antibody

  • 货号：
    CSB-PA657730
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA657730(ADAMTS6 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA657730(ADAMTS6 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UKP5
  • 基因名：
    ADAMTS6
  • 别名：
    ADAMTS6 antibody; A disintegrin and metalloproteinase with thrombospondin motifs 6 antibody; ADAM-TS 6 antibody; ADAM-TS6 antibody; ADAMTS-6 antibody; EC 3.4.24.- antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ADAMTS6
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. PMID: 30012220
    2. High ADAMTS-6 expression is a marker of poor prognosis in patients with esophageal squamous cell carcinoma. PMID: 29475036
    3. Using siRNA, over-expression and mutagenesis, it was found ADAMTS6 inhibits and ADAMTS10 is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition. PMID: 27779234
    4. ADAMTS6 inhibits breast tumor development by regulating the ERK pathway via binding of miR-221-3p PMID: 27542224
    5. Novel inguinal hernia susceptibility genes are identified as EFEMP1, WT1, EBF2 and ADAMTS6. PMID: 26686553
    6. Study shows that the ADAMTS6 transcript contains unusually large untranslated regions (UTRs) at both the 5' and 3'end, and the 5'UTR contains 11 AUG codons upstream of the predicted ADAMTS6 start codon. PMID: 16129570
    7. The gain of function studies indicated that ADAM metallopeptidase with thrombospondin type 1 motif 6 activate NR5A1 gene expression. PMID: 18579725

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 组织特异性：
    Expressed at low levels in placenta and barely detectable in a number of other tissues.
  • 数据库链接：

    HGNC: 222

    OMIM: 605008

    KEGG: hsa:11174

    STRING: 9606.ENSP00000370443

    UniGene: Hs.482291