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ADAMTS2 Antibody

  • 货号：
    CSB-PA576816
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of HepG2 K562 Hela Colo using ADAMTS-2 antibody.. Secondary antibody was diluted at 1:20000
  • 其他：

产品详情

  • Uniprot No.：
    O95450
  • 基因名：
    ADAMTS2
  • 别名：
    A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody; ADAM TS 2 antibody; ADAM TS2 antibody; ADAM-TS 2 antibody; ADAM-TS2 antibody; ADAMTS 3 antibody; ADAMTS-2 antibody; ADAMTS2 antibody; ATS2_HUMAN antibody; EC 3.4.24.14 antibody; EDS VIIB antibody; EDS VIIC antibody; hPCPNI antibody; NPI antibody; PC I NP antibody; PC I-NP antibody; PCINP antibody; PCPNI antibody; pNPI antibody; Procollagen I N proteinase antibody; Procollagen I N-proteinase antibody; Procollagen I/II amino propeptide processing enzyme antibody; Procollagen I/II amino propeptide-processing enzyme antibody; Procollagen N endopeptidase antibody; Procollagen N-endopeptidase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human ADAMTS-2. at AA rangle: 1140-1211
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
  • 基因功能参考文献：
    1. We identified three novel homozygous loss-of-function mutations (c.2927_2928delCT, p.(Pro976Argfs*42); c.669_670dupG, p.(Pro224Argfs*24); and c.2751-2A>T) and one compound heterozygous mutation (c.2T>C, p.? and c.884_887delTGAA, p.(Met295Thrfs26*)) in ADAMTS2 in five patients from four unrelated families PMID: 26765342
    2. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review] PMID: 25863161
    3. IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression. PMID: 26232334
    4. ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD PMID: 25674217
    5. Pathway inhibition studies revealed that ADAMTS-2 upregulation by IL-6 was mediated by JNK pathway. PMID: 24752352
    6. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis. PMID: 20574651
    7. Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein. PMID: 16046392
    8. when conditioned media of TSP2-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 is a potential inhibitor of angiogenesis PMID: 11788898
    9. Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function PMID: 15373769

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  • 相关疾病：
    Ehlers-Danlos syndrome 7C (EDS7C)
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 组织特异性：
    Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
  • 数据库链接：

    HGNC: 218

    OMIM: 225410

    KEGG: hsa:9509

    STRING: 9606.ENSP00000251582

    UniGene: Hs.23871