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ADAMTS12 Antibody

  • 货号：
    CSB-PA001300LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001300LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADAMTS12 Polyclonal antibody
  • Uniprot No.：
    P58397
  • 基因名：
    ADAMTS12
  • 别名：
    ADAMTS12 antibody; UNQ1918/PRO4389A disintegrin and metalloproteinase with thrombospondin motifs 12 antibody; ADAM-TS 12 antibody; ADAM-TS12 antibody; ADAMTS-12 antibody; EC 3.4.24.- antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12 protein (26-229AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ADAMTS12 Antibody (CSB-PA001300LA01HU)，的标记方式是Non-conjugated。对于ADAMTS12 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001300LB01HU ADAMTS12 Antibody, HRP conjugated ELISA
    FITC CSB-PA001300LC01HU ADAMTS12 Antibody, FITC conjugated
    Biotin CSB-PA001300LD01HU ADAMTS12 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.
  • 基因功能参考文献：
    1. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. PMID: 29135310
    2. ADAMTS12 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    3. Decreased levels of ADAMTS-12 were found to be associated with intrahepatic cholestasis of pregnancy. PMID: 26363034
    4. ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review] PMID: 24876675
    5. ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis. PMID: 23019333
    6. Our results suggest that ADAMTS12 may be a susceptibility gene for RA development. PMID: 22505177
    7. statistically significant increase in mRNA expression of ADAMTS-7 and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs PMID: 22247065
    8. The data supported the hypothesis that genetic variations in ADAMTS12 influence the risk of schizophrenia. PMID: 22322903
    9. expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development PMID: 21559743
    10. This study identifies a novel biological role for ADAMTS-12, and highlights the importance and complexity of its non-proteolytic domain(s) pertaining to its function. PMID: 21494557
    11. ADAMTS-12 is a new COMP-interacting and -degrading enzyme and thus may play an important role in the COMP degradation in the initiation and progression of arthritis PMID: 16611630
    12. data suggest that ADAMTS12 confers tumour-protective functions upon cells that produce this proteolytic enzyme PMID: 17895370
    13. ADAMTS-7 and ADAMTS-12 are newly identified enzymes responsible for cartilage oligomeric matrix protein degradation in arthritis. PMID: 19098927
    14. Results demonstrate that ADAMTS-12, a downstream molecule of PTHrP signaling, is a novel regulator of chondrogenesis. PMID: 19151918
    15. ADAMTS-12 is a novel anti-tumor protease that can reduce the proliferative properties of tumor cells. PMID: 19638407

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 组织特异性：
    Expressed in skeletal muscle and fat.
  • 数据库链接：

    HGNC: 14605

    OMIM: 606184

    KEGG: hsa:81792

    STRING: 9606.ENSP00000422554

    UniGene: Hs.12680