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ACY1 Antibody

  • 货号：
    CSB-PA860799ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ACY1 antibody at 4µg/ml
      Lane 1: K562 whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 46, 38, 39, 43 kDa
      Observed band size: 46 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA860799ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA860799ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ACY1 Polyclonal antibody
  • Uniprot No.：
    Q03154
  • 基因名：
    ACY1
  • 别名：
    ACY 1 antibody; ACY-1 antibody; Acy1 antibody; ACY1_HUMAN antibody; ACY1D antibody; ACYLASE antibody; Acylase I antibody; Aminoacylase 1 antibody; Aminoacylase-1 antibody; EC 3.5.1.14 antibody; epididymis secretory protein Li 5 antibody; HEL-S-5 antibody; N acyl L amino acid amidohydrolase antibody; N-acyl-L-amino-acid amidohydrolase antibody; OTTHUMP00000212459 antibody; OTTHUMP00000212462 antibody; OTTHUMP00000212463 antibody; OTTHUMP00000212464 antibody; OTTHUMP00000212465 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Aminoacylase-1 protein (1-408AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of N-acetylated amino acids to acetate and free amino acids.
  • 基因功能参考文献：
    1. with the elevated level in the disease progression of Chronic hepatitis B (CHB), ACY1 autoantibody may be a valuable serum biomarker for discriminating HBVrelated liver cirrhosis from CHB. PMID: 27633755
    2. Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts. PMID: 24117009
    3. ACY1 acts as a tumor suppressor in hepatocellular carcinoma. PMID: 24846301
    4. Report serum aminoacylase-1 as a novel biomarker with potential prognostic utility for long-term outcome in renal transplant recipients with delayed graft function. PMID: 23739232
    5. Case Report: ACY1-deficient patient presenting with autistic features. PMID: 20480396
    6. We concluded that ACY1 expression in colorectal cancer varies with stage and appears to play a role in cell proliferation and apoptosis PMID: 23317546
    7. These data suggest that aminoacylase expression is dysregulated in neuroblastoma. PMID: 21128244
    8. aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis PMID: 21414403
    9. by complementing different active site mutants of human aminoacylase-1, study shows that catalysis occurs at the dimer interface PMID: 12933810
    10. first report of a patient with aminoacylase I deficiency PMID: 16274666
    11. Genetic deficiency of ACY1 leads to functional ACY1 deficiency and excretion of N-acetylated amino acids. PMID: 16465618
    12. Because hK1 amidase activity is significantly lower in urine of systolic HF patients, it can be supposed that activity of renal kallikrein-kinin system may be suppressed in this systolic heart failure. PMID: 17045186
    13. T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids PMID: 18341290

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  • 相关疾病：
    Aminoacylase-1 deficiency (ACY1D)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase M20A family
  • 组织特异性：
    Expression is highest in kidney, strong in brain and weaker in placenta and spleen.
  • 数据库链接：

    HGNC: 177

    OMIM: 104620

    KEGG: hsa:95

    STRING: 9606.ENSP00000384296

    UniGene: Hs.334707