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ACSL6 Antibody

  • 货号：
    CSB-PA634338
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO cells and Jurkat cells, using ACSL6 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ACSL6 Polyclonal antibody
  • Uniprot No.：
    Q9UKU0
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human ACSL6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
  • 基因功能参考文献：
    1. ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation PMID: 27647415
    2. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked PMID: 22205969
    3. The alternative fatty acid Gate-domain motifs are essential determinants for the activity of the human ACSL6 isoforms, which appear to act as homodimeric enzyme as well as in complex with other spliced forms. PMID: 20429931
    4. The t(5;12)(q23-31;p13)translocation with ETV6-ACSL6 genomic alteration rearrangement in polycythemia vera patients was reported. PMID: 16572202
    5. Analyses did not yield convincing evidence for associations of schizophrenia with ACSL6 PMID: 16827919
    6. Three ACSL6 spliced variants of a mutually exclusive exon pair are reported, they encode a slightly different short motif which contains a conserved structural domain, the fatty acid Gate domain. PMID: 16834775
    7. haplotypes underlying the SPEC2/PDZ-GEF2/ACSL6 region are associated with schizophrenia PMID: 17030554
    8. The acyl-coenzyme A synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 was associated with premature ovarian failure and identified disease-susceptibility haplotypes. PMID: 18555221
    9. ACSL6 is highly associated with schizophrenia and several haplotypes in this haploblock have about twofold to 10-fold increase in the affected subjects in Han Chinese. PMID: 18718982

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  • 相关疾病：
    A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.
  • 亚细胞定位：
    Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
  • 蛋白家族：
    ATP-dependent AMP-binding enzyme family
  • 组织特异性：
    Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
  • 数据库链接：

    HGNC: 16496

    OMIM: 604443

    KEGG: hsa:23305

    STRING: 9606.ENSP00000296869

    UniGene: Hs.14945