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ACSF3 Antibody

  • 货号：
    CSB-PA674579LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA674579LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA674579LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ACSF3 Polyclonal antibody
  • Uniprot No.：
    Q4G176
  • 基因名：
    ACSF3
  • 别名：
    ACSF3 antibody; PSEC0197Malonate--CoA ligase ACSF3 antibody; mitochondrial antibody; EC 6.2.1.n3 antibody; Acyl-CoA synthetase family member 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ACSF3 Antibody (CSB-PA674579LA01HU)，的标记方式是Non-conjugated。对于ACSF3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA674579LB01HU ACSF3 Antibody, HRP conjugated ELISA
    FITC CSB-PA674579LC01HU ACSF3 Antibody, FITC conjugated
    Biotin CSB-PA674579LD01HU ACSF3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
  • 基因功能参考文献：
    1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism PMID: 28479296
    2. ACSF3 was significantly upregulated, and was involved in fatty acid and lipid metabolism and accelerated liver injury in alcoholic liver disease. PMID: 23337955
    3. data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma. PMID: 22420028
    4. ACSF3 is a candidate gene for non-classical CMAMMA observed in our patients. PMID: 21785126
    5. Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. PMID: 21846720
    6. mutations in ACSF3, encoding a putative methylmalonyl-CoA and malonyl-CoA synthetase, were identified as a cause of combined malonic and methylmalonic aciduria. PMID: 21841779

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  • 相关疾病：
    Combined malonic and methylmalonic aciduria (CMAMMA)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    ATP-dependent AMP-binding enzyme family
  • 数据库链接：

    HGNC: 27288

    OMIM: 614245

    KEGG: hsa:197322

    STRING: 9606.ENSP00000320646

    UniGene: Hs.461727