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ACRBP Antibody

  • 货号：
    CSB-PA003609
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HepG2 cells using OY-TES-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8NEB7
  • 基因名：
    ACRBP
  • 别名：
    ACRBP antibody; ACRBP_HUMAN antibody; acrosin binding protein antibody; Acrosin binding protein precursor antibody; Acrosin-binding protein antibody; Cancer/testis antigen 23 antibody; Cancer/testis antigen OY TES 1 antibody; Cancer/testis antigen OY-TES-1 antibody; CT23 antibody; FLJ51160 antibody; OY TES 1 antibody; Proacrosin binding protein sp32 antibody; Proacrosin-binding protein sp32 antibody; SP32 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human OY-TES-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.
  • 基因功能参考文献：
    1. Down regulation of OY-TES-1 increased expression of apoptosis-regulated protein caspase-3, and decreased expression of cell cycle-regulated protein cyclin E, migration/invasion-regulated proteins MMP2 and MMP9. PMID: 26339343
    2. OY-TES-1 downregulation in liver cancer cells caused 2 opposite effects on cell proliferation: promotion by upregulating CCND2 and CDCA3, and inhibition by CD9 upregulation and NANOG downregulation. OY-TES-1 may play multiple roles in liver cancer. PMID: 25673160
    3. OY-TES-1 was expressed in ovarian cancer (OC) tissues with a high proportion, and some of OC tissues presented OY-TES-1 expression in high level vs OC adjacent tissues. PMID: 26189257
    4. OY-TES-1 is frequently expressed in colorectal carcinoma and is able to induce humoral immune response spontaneously in CRC patients. PMID: 24294369
    5. The down-regulation of OY-TES-1 expression in bone marrow-derived mesenchymal stem cells caused cell growth inhibition, cell cycle arrest, apoptosis induction and migration ability attenuation. PMID: 22651134
    6. High ACRBP expression correlated with reduced survival time and faster relapse among ovarian cancer patients. PMID: 20876808
    7. We showed identification of HLA-A24-binding OY-TES-1 peptide, TES(401-409) (KTPFVSPLL) recognized by CD8 T-cells. PMID: 16301813

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.
  • 组织特异性：
    Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.
  • 数据库链接：

    HGNC: 17195

    OMIM: 608352

    KEGG: hsa:84519

    STRING: 9606.ENSP00000229243

    UniGene: Hs.123239