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ABI3BP Antibody

  • 货号：
    CSB-PA729627
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA729627(ABI3BP Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA729627(ABI3BP Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z7G0
  • 基因名：
    ABI3BP
  • 别名：
    ABI gene family member 3 (NESH) binding protein antibody; ABI gene family member 3 binding protein antibody; ABI gene family member 3-binding protein antibody; ABI3BP antibody; FLJ41743 antibody; FLJ41754 antibody; Nesh binding protein antibody; Nesh BP antibody; Nesh-binding protein antibody; NeshBP antibody; Target of Nesh SH3 antibody; Target of Nesh-SH3 antibody; Tarsh antibody; TARSH_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human ABI3BP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. ABI3BP is a susceptibility gene for Kashin-Beck disease in the Chinese Han population. PMID: 24442417
    2. Thus, TARSH presumably represents a trigger gene for evoking cellular senescence, which has also been suggested to be involved in the prevention of tumorigenesis. PMID: 15752759
    3. expression of TARSH mRNA is remarkably downregulated in all lung cancer cell lines examined; also TARSH expression was significantly low in all of the tumor specimens when compared to the expression in corresponding non-neoplastic lung tissue specimens PMID: 16205947
    4. The loss of ABI3BP expression could play a functional role in thyroid tumorigenesis. PMID: 18559958
    5. These results suggest that TARSH plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development. PMID: 19338757

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  • 相关疾病：
    Defects in ABI3BP has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in brain, heart, lung, liver, pancreas kidney and placenta.
  • 数据库链接：

    HGNC: 17265

    OMIM: 606279

    KEGG: hsa:25890

    STRING: 9606.ENSP00000284322

    UniGene: Hs.477015