Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ABI2 Antibody

ABI2 Antibody

  • 货号：
    CSB-PA001102GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYB9
  • 基因名：
  • 别名：
    Abelson interactor 2 antibody; ABI 2 antibody; Abi-2 antibody; ABI2 antibody; ABI2_HUMAN antibody; ABI2B antibody; Abl binding protein 3 antibody; Abl interacting protein 1 (SH3 containing protein) antibody; Abl interactor 2 antibody; Abl interactor protein 2b antibody; Abl-binding protein 3 antibody; AblBP3 antibody; AIP 1 antibody; Arg binding protein 1 antibody; Arg protein tyrosine kinase binding protein antibody; Arg-binding protein 1 antibody; ArgBP1 antibody; ARGBPIA antibody; ArgBPIB antibody; OTTHUMP00000163783 antibody; OTTHUMP00000163784 antibody; OTTHUMP00000206182 antibody; OTTHUMP00000206183 antibody; OTTHUMP00000206184 antibody; OTTHUMP00000206185 antibody; SSH3BP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ABI2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells.
  • 基因功能参考文献：
    1. TIS21 attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS-ABI2-DRF signal cascade PMID: 27932314
    2. Abl-interactor 2 (ABI2) is a novel MLL translocation partner in acute myeloid leukemia. PMID: 22304832
    3. Abi-2 may have a key regulatory function in leiomyomas cellular/tissue structural organization during growth and regression PMID: 16488906
    4. disruption of the interaction between Bcr-Abl and Abi1 by mutations either in Bcr-Abl or Abi1 not only abolished tyrosine phosphorylation of Abi1 and membrane translocation of Abi1/WAVE2 PMID: 17389688
    5. TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Abl-interactor 2 PMID: 18632609

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Nucleus.; [Isoform 1]: Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Cell junction, adherens junction.
  • 蛋白家族：
    ABI family
  • 组织特异性：
    Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
  • 数据库链接：

    HGNC: 24011

    OMIM: 606442

    KEGG: hsa:10152

    UniGene: Hs.471156