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ABCF1 Antibody

  • 货号：
    CSB-PA554269
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HeLa/COLO205 cells, using ABCF1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ABCF1 Polyclonal antibody
  • Uniprot No.：
    Q8NE71
  • 基因名：
    ABCF1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human ABCF1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
  • 基因功能参考文献：
    1. The high copy number variant in the ABCF1 gene was the strongest risk factor for gout. PMID: 28405828
    2. ABCF1 extrinsically regulates retinal pigment epithelial cell phagocytosis of shed photoreceptor outer segments. PMID: 25904329
    3. Elevated microRNA-23a Expression Enhances the Chemoresistance of Colorectal Cancer Cells with Microsatellite Instability to 5-Fluorouracil by Directly Targeting ABCF1 PMID: 25929864
    4. expression of ABC50 mutants, which cannot hydrolyse ATP, decreases general translation and relaxes the discrimination against the use of non-AUG codons at translation start sites. PMID: 25597744
    5. A rare copy number variation of the ABCF1 gene was detected among dengue patients from Malaysia. PMID: 24634119
    6. The results suggested that SNPs at PRR3 and ABCF1 genes and the haplotype composed by SNPs at GNL1 and PRR3 between the HLA-A and HLA-C genes tended to predict Graves ophthalmology in a gender-dependent manner in patients with Graves disease in Taiwan. PMID: 24908204
    7. ABCF1 showed a significant increase in expression after escitalopram treatment. PMID: 23719290
    8. ABCF1 is a critical protein that associates with viral double-stranded DNA. PMID: 23263557
    9. The two critical HLA regions for susceptibility to autoimmune pancreatitis are limited to the HLA-DRB1*0405-DQB1*0401 in the class II and the ABCF1in the class I regions. PMID: 17119950
    10. ABC50 N-terminal region interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2 PMID: 17894550
    11. ABC50 plays a key role in translation initiation and has functions that are distinct from those of other non-membrane ABC proteins. PMID: 19570978

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  • 亚细胞定位：
    [Isoform 2]: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope.
  • 蛋白家族：
    ABC transporter superfamily, ABCF family, EF3 subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 70

    OMIM: 603429

    KEGG: hsa:23

    STRING: 9606.ENSP00000313603

    UniGene: Hs.655285