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ABCE1 Antibody

  • 货号：
    CSB-PA001076ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ABCE1 antibody at 4μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: k562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 67 kDa
      Observed band size: 67 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001076ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001076ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ABCE1 Polyclonal antibody
  • Uniprot No.：
    P61221
  • 基因名：
    ABCE1
  • 别名：
    2' 5' oligoadenylate binding protein antibody; 2''-5''-oligoadenylate-binding protein antibody; 2'5' oligoadenylate binding protein antibody; ABC 38 antibody; ABC38 antibody; ABCE 1 antibody; ABCE1 antibody; ABCE1_HUMAN antibody; ATP binding cassette sub family E (OABP) member 1 antibody; ATP binding cassette sub family E member 1 antibody; ATP-binding cassette sub-family E member 1 antibody; HuHP 68 antibody; HuHP68 antibody; OABP antibody; Ribonuclease 4 inhibitor antibody; Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor antibody; Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor antibody; Ribonuclease L inhibitor antibody; RLI antibody; RNase L inhibitor antibody; RNASEL1 antibody; RNASELI antibody; RNS 4I antibody; RNS4I antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ATP-binding cassette sub-family E member 1 protein (320-599AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Plays a role in the regulation of mRNA turnover. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway.; (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly.; (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
  • 基因功能参考文献：
    1. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. PMID: 27681415
    2. ABCE1 is involved in histone biosynthesis and DNA replication and therefore is essential for normal S phase progression. PMID: 26985706
    3. The present study reported on the effects of ABCE1 overexpression on lung adenocarcinoma cells in vitro, demonstrating its enhancing effect on cell proliferation and invasiveness with simultaneous downregulation of p27 protein expression. PMID: 27314749
    4. ABCE1 plays an essential role in the progression and metastasis of lung cancers and may represent a valuable therapeutic target for the management of lung tumor PMID: 26733164
    5. miR-299-3p promotes the sensibility of lung cancer to doxorubicin through suppression of ABCE1, at least partly. Therefore, the disordered decreased of miR-299-3p and resulting ABCE1 up-expression may contribute to chemoresistance of lung cancer PMID: 26617714
    6. Expression of the ABCE1-silencing gene, transfected by electrotransfer, could inhibit the proliferation, invasion, and migration of thyroid cancer cells. PMID: 26600528
    7. Downregulation of ABCE1 via siRNA affects the sensitivity of lung cancer cells against chemotherapeutic agents. PMID: 25744244
    8. ABCE1 is closely associated with cell proliferation, invasion and migration in esophageal cancer and silencing the ABCE1 gene by electroporation can significantly reduce the proliferation, invasion and migration capacity PMID: 25815591
    9. ABCE1 is able to suppress RNA silencing in Nicotiana benthamiana plants, in mammalian HEK293 cells and in the worm Caenorhabditis elegans. PMID: 25659154
    10. ABCE1 is closely connected with the pathogenesis and development of oral cancer, which acts through the cellular pathways of 2-5A/RNase L. PMID: 25337191
    11. ABCE1 is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of 2-5A/RNase L. PMID: 24551278
    12. Studies indicate a strong sequence conservation of ABC-type ATPase ABCE1 in eukaryotes and archaea. PMID: 23266104
    13. ABCE1 protein regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis. (Review) PMID: 23008114
    14. Pulse chase experiments and immunoelectron microscopy shows that HIV-1 Gag associates transiently with ABCE1 during HIV-1 capsid assembly, including at the plasma membrane where assembly is completed. PMID: 17233757
    15. HIV-1, HIV-2, SIV mac239, and SIVagm Gag proteins form ABCE1-containing assembly intermediates during immature capsid formation, indicating that Gag proteins of these diverse retroviruses bind to ABCE1 despite the limited homology between these Gags. PMID: 14747530
    16. For binding of WT HIV-1 Gag to the cellular ATPase ABCE1, which facilitates HIV-1 capsid assembly, the basic residues in the nucleocapsid domain of Gag are required but the cysteine and histidine residues in the nucleocapsid domain are dispensable. PMID: 16275648
    17. During assembly of an immature HIV-1 capsid, HIV-1 Gag progresses through a pathway of sequential assembly intermediates that contain ABCE1, a cellular ATPase that was found to facilitate capsid formation. PMID: 11780123
    18. To form HIV-1 capsid assembly intermediates, HIV-1 Gag co-opts a complex found in infected and uninfected cells that contains the cellular ATPase ABCE1 and the RNA helicase DDX6, both of which facilitate HIV-1 capsid assembly. PMID: 22851315
    19. Report high expression level of ABCE1 mRNA and protein in human lung adenocarcinoma tissues and metastatic lymph nodes, which was also correlated with clinical stages. PMID: 22267055
    20. Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. PMID: 21448132
    21. Results suggest that ABCE1 plays an important role in the pathogenesis of human small cell lung cancer cell. PMID: 20372810
    22. NTP hydrolysis by ABCE1 is stimulated by posttermination complexes and is required for its ribosomal recycling activity. PMID: 20122402
    23. were able to confirm the excess of rare genetic variation among HIV-1-positive African-American individuals (n=53; Tajima's D=-2.34). These results highlight the potential importance of ABCE1's role in infectious diseases such as HIV-1. PMID: 19657357
    24. HIV-2 Gag associates with human HP68 in a cell-free system and that Gag proteins of HIV-2, simian immunodeficiency virus SIVmac239, and SIVagm associate with endogenous HP68 in primate cells, as is seen for HIV-1. PMID: 14747530
    25. overexpression in a permissive cell line had no significant effect on varicella zoster virus replication PMID: 15107989
    26. ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients. PMID: 15809757
    27. The primary role of ABCE-1 in the effect of TULA appears to be the recruitment of TULA to the sites of HIV-1 assembly where TULA interferes with the late steps of the HIV-1 life cycle. PMID: 18006034
    28. host protein essential for assembly of immature HIV-1 capsids PMID: 11780123

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  • 亚细胞定位：
    Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.
  • 蛋白家族：
    ABC transporter superfamily, ABCE family
  • 数据库链接：

    HGNC: 69

    OMIM: 601213

    KEGG: hsa:6059

    STRING: 9606.ENSP00000296577

    UniGene: Hs.12013