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ABCC2 Antibody

  • 货号：
    CSB-PA223592
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA223592(ABCC2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q92887
  • 基因名：
    ABCC2
  • 别名：
    ABC30 antibody; abcC2 antibody; ATP binding cassette sub family C (CFTR/MRP) member 2 antibody; ATP binding cassette subfamily C member 2 antibody; ATP-binding cassette sub-family C member 2 antibody; Canalicular multidrug resistance protein antibody; Canalicular multispecific organic anion transporter 1 antibody; CMOAT antibody; CMOAT1 antibody; cMRP antibody; DJS antibody; KIAA1010 antibody; MRP 2 antibody; MRP2_HUMAN antibody; Multidrug resistance associated protein 2 antibody; Multidrug resistance-associated protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ABCC2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transport various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine.
  • 基因功能参考文献：
    1. Promoter ABCC2 -24C>T SNP affects both triglyceride levels and the TG/HDL-C ratio after short-term low-dose atorvastatin treatment in male but not female hypercholesterolaemic individuals. PMID: 29178257
    2. genetic variability in the ABCC2 gene influences the in vitro expression, trafficking, and transport activity of MRP2 PMID: 28405913
    3. Polymorphisms of GSTP1 rs1695 and ABCC2 rs717620 can be used to predict the outcomes of Uygur patients with advanced NSCLC who have received platinum-based chemotherapy. Kaplan-Meier survival analysis indicated that survival with GSTP1 AG+ GG was significantly longer than in patients with AA gene (P<0.05), and survival with ABCC2 CT + TT was significantly longer than in patients with CC gene. PMID: 28442702
    4. Results show that the response to treatment depended of the variability in genes engaged in drugs' transport ABCC2 c.-24C>T and ABCB1 p.Ser893Ala/Thr and in DNA repair machinery ERCC2 p.Lys751Gln. PMID: 27527855
    5. Self-inhibition of the MRP2-dependent secretion of MTX is a plausible explanation for the time-dependent PKs of this drug. PMID: 28196047
    6. SMS regulates the expression and function of drug transporters P-gp and MRP2. PMID: 27394416
    7. genetic association studies in a population in France: Data that SNPs in ABCC2 are associated with regulation of secretion of endogenous organic anions; the 3 SNPs investigated (-24C>T, exon 1, rs717620; c.3972C>T, exon 28, rs3740066; c.1249G>A, exon 10, rs2273697) are associated with differential excretion of 35 of the 108 metabolites analyzed. PMID: 28532626
    8. BCRP and MRP2 can mediate elimination of ochratoxin A from cells, reducing OTA toxicity. PMID: 28532671
    9. Four SNPs within the APOE cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1/PSRC1 (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80 PMID: 27943270
    10. We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2. PMID: 27180762
    11. In the present review we focus on the role of MRP2 in the apical membrane of the enterocytes, as an important component of this intestinal barrier, as well as on its regulation and provide a detailed compilation of significant contributions demonstrating that MRP2 expression and function vary under relevant physiological and pathophysiological conditions PMID: 27109321
    12. ABCC2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients. PMID: 27590272
    13. Meta-analysis. The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs. PMID: 27816260
    14. we have investigated the role of ABCB1 rs1045642 and rs2032582 and ABCC2 rs2273697 and rs717620 in antiepileptic drug-resistance. Our study suggests that the ABCC2 rs717620 polymorphism is associated with resistance to antiepileptic drugs in Chinese patients with epilepsy. PMID: 27886333
    15. A novel deletion in ABCC2 gene was identified in families with dual hereditary jaundice. PMID: 26350512
    16. Resveratrol-3-O-sulfate reduced in both MRP2-overexpressing MDCKII-UGT1A1 cells and Human UGT1A9-overexpressing HeLa cells. PMID: 26502886
    17. A thalassemia patient has been found to be a carrier of UGT1A1 and ABCC2 polymorphisms explaining a possible reduction of desferasirox metabolism together with a reduction of biliary elimination by MRP2 and causing a serious adverse reaction. PMID: 26403473
    18. ABCC2 expression in PBMCs may be, in part, influenced by gender, and that at least two endogenous control genes should be utilized. PMID: 26681017
    19. Activation of liver PKCs during cholestasis leads to Ezrin Thr567 phosphorylation resulting in MRP2 internalization and degradation where ubiquitin ligase E3 GP78 is involved. PMID: 26212029
    20. These studies identify Akt2 as a critical kinase that regulates radixin phosphorylation and leads to Mrp-2 translocation and function. PMID: 26500117
    21. MRP2 expression in HepG2 cells is repressed by IL-18. PMID: 26292095
    22. MRP 2 expression is upregulated by ATP in colorectal cancer cells and enhances their survival to chemotherapeutic drugs. PMID: 26295158
    23. There was no association of ABCC2 with risk of colorectal cancer. PMID: 26109419
    24. CYP3A4*22 and ABCC2 haplotypes did not influence tacrolimus trough concentrations PMID: 26067485
    25. ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2. PMID: 25890497
    26. Data show the influence of ABCC2 and ABCC4 polymorphisms on tenofovir plasma concentrations in Thai HIV-infected patients PMID: 25801567
    27. this study found that ABCC2 and ABCG2 expression levels were altered already in mild/moderate dysplasia in carcinogenesis PMID: 25793771
    28. Data suggest that hepatic expression of MRP3 is up-regulated and canalicular localization of MRP2 is altered in pediatric patients with advanced nonalcoholic steatohepatitis; these alterations may be involved in changes observed in drug metabolism. PMID: 25788542
    29. This study revealed that three polymorphisms, SCN1A IVS5-91G>A, ABCC2 c.1249 G>A and UGT2B7 c.802T>C, are associated with OXC maintenance dose and lnCDR in Han Chinese epilepsy patients PMID: 25823783
    30. The recessive model of G1249A in MRP2/ABCC2 might decrease the risk of drug resistance in Asian epilepsy. PMID: 25847339
    31. Data (including data from studies on cloned Caco-2 cells with transporter genes knocked-out) verify that MRP2, MDR1, and BCRP are responsible for transport of specific xenobiotics (transport of estrone 3-sulfate and nitrofurantoin by MRP2). PMID: 25388687
    32. Clinically, no significant association was observed for the ABCC2 genetic variants and CBZ treatment outcomes. This comprehensive analysis does not support a role for ABCC2 in CBZ treatment efficacy. PMID: 24567120
    33. Single nucleotide polymorphisms in ABCC2 gene is associated with acute graft-versus-host disease. PMID: 25425682
    34. HIV-infected patients who carry ABCC2*1C genotype CC at position -24 or have high plasma tenofovir concentration are at risk of decreased glomerular filtration rate. PMID: 24788661
    35. Our results suggest the ABCC2 T -24 G 1249 T 3972 haplotype was associated with imatinib resistance in chronic myeloid leukaemia PMID: 25060527
    36. MRP2 was involved in the efflux of herbal prpearations which would be useful for the safe application of these components or their herbs PMID: 25744397
    37. Significant allele association of ABCC2 rs2273697 was observed in Chinese females with epilepsy. PMID: 24624913
    38. This study suggested that SCN1A and ABCC2 polymorphisms may be associated with the response to CBZ/OXC in the Chinese Han population PMID: 25155934
    39. there is strong data that ABCC2 -24C>T is associated with decreased gene expression PMID: 25162314
    40. NHERF1 is essential for maintaining the localization and function of Mrp-2. PMID: 25163515
    41. ABCB1, ABCB4 and ABCC2 polymorphisms do not have a role in enhancing risk of drug-induced hepatotoxicity in a Spanish cohort PMID: 24732756
    42. This observation may suggest a differential suppression of ABCC2 by miR-379 caused by haplotype-dependent differences in mRNA secondary structures, resulting in changes in mRNA target accessibility or mRNA stability PMID: 24743544
    43. Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog. PMID: 24641901
    44. Genotyping for 3972CT and 1249GA ABCC2 gene variants maybe useful in acute lymphoblastic leukemia to optimize methotrexate therapy and reducing the associated toxicity PMID: 24552501
    45. The ABCC2 G1249A polymorphism is significantly associated with a decreased risk of antiepileptic drug resistance. PMID: 24325761
    46. This study provides the first evidence that the -24T allele in ABCC2 gene is associated with the severity of MTX toxicities. PMID: 24404132
    47. population pharmacokinetics modelling showed that ABCC2 -24T allele (rs717620) had a combined influence on both MTX elimination and distribution PMID: 23069858
    48. Cholesterol increases the transport rates of ABCB11 and ABCC2, but with the latter, may also modify the binding site as for E17betaG PMID: 24711118
    49. ABCB1, ABCC1, and ABCC2 single nucleotide polymorphisms are associated with Glasgow Outcome Scale (GOS) score after traumatic brain injury. PMID: 23896815
    50. ABCC2 haplotype as well as CYP3A5 polymorphism have significant impacts on the pharmacokinetics of tacrolimus. PMID: 23633119

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  • 相关疾病：
    Dubin-Johnson syndrome (DJS)
  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 组织特异性：
    Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
  • 数据库链接：

    HGNC: 53

    OMIM: 237500

    KEGG: hsa:1244

    STRING: 9606.ENSP00000359478

    UniGene: Hs.368243