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ABCC10 Antibody

  • 货号：
    CSB-PA003282
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using MRP7 Polyclonal Antibody
    • Western Blot analysis of Jurkat A549 cells using MRP7 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q5T3U5
  • 基因名：
    ABCC10
  • 别名：
    ABCC10 antibody; ATP binding cassette; sub family C (CFTR/MRP); member 10 antibody; ATP binding cassette; subfamily C; member 10 antibody; ATP-binding cassette sub-family C member 10 antibody; EST182763 antibody; mFLJ00002 antibody; MRP7 antibody; MRP7_HUMAN antibody; Multidrug resistance associated protein 7 antibody; Multidrug resistance-associated protein 7 antibody; SIMRP7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MRP7.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.
  • 基因功能参考文献：
    1. FOXM1 promotes 5-FU resistance by up-regulating ABCC10 expression in colorectal tumor cells. PMID: 28051999
    2. It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation. PMID: 28612064
    3. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance. PMID: 26655271
    4. the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10 PMID: 24431074
    5. ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays. PMID: 24937672
    6. This report describes the ATPase activity of ABCC10 and further revealed ABCC10 localizes basolaterally using an in vitro system. The described work also identifies the tyrosine kinase sorafenib as an inhibitor of ABCC10. PMID: 23087055
    7. Study establishes that ABCC10 is able to modulate taxane resistance in vivo using a mouse model. PMID: 21576088
    8. Study establishes that ABCC10 confers resistance to several classes of agents including nucleoside analogs (cytabarine, dideoxycytidine) and epothilone B. PMID: 19118001
    9. This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro. PMID: 15256465
    10. First study to describe ABCC10's ability to transport physiological substrates, confirming that this protein, with low identity to ABCC1, was indeed a efflux pump. PMID: 12527806
    11. First study to describe structure and expression pattern of this transporter. PMID: 11146224
    12. Tetrandrine and 5-bromotetrandrine can both reverse multidrug resistance in K562 cells by reducing expression of MRP7. PMID: 22739155
    13. Multivariate regression analysis identified carriage of a composite genotype of ABCC10 rs2125739 to be associated with nevirapine plasma concentrations PMID: 22082652
    14. Tenofovir is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence tenofovir renal tubular transport and contribute to the development of kidney tubular dysfunction. PMID: 21628669
    15. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10) PMID: 19841739
    16. MRP7 has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification. PMID: 12527806
    17. The genomic organization and gene expression regulation of human multidrug resistance-associated protein 7 and a splicing variant MRP7A were identified PMID: 12566991
    18. A non-major histocompatibility complex MRP7 leader peptide ALALVRMLI binds to HLA-E and strongly inhibits natural killer (NK) cell-mediated lysis PMID: 16034073
    19. MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma PMID: 17203221
    20. ABCC10/MRP7 may confer vinorelbine resistance in non-small cell lung cancer PMID: 19082471

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 组织特异性：
    [Isoform 1]: Specifically expressed in spleen.; [Isoform 2]: Widely expressed.
  • 数据库链接：

    HGNC: 52

    OMIM: 612509

    KEGG: hsa:89845

    STRING: 9606.ENSP00000361608

    UniGene: Hs.55879