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ABCA5 Antibody

  • 货号：
    CSB-PA845163LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA845163LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA845163LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ABCA5 Polyclonal antibody
  • Uniprot No.：
    Q8WWZ7
  • 基因名：
    ABCA5
  • 别名：
    ABC13 antibody; ABCA5 antibody; ABCA5_HUMAN antibody; ATP binding cassette sub family A (ABC1) member 5 antibody; ATP binding cassette A5 antibody; ATP binding cassette sub family A member 5 antibody; ATP-binding cassette sub-family A member 5 antibody; DKFZp451F117 antibody; DKFZp779N2435 antibody; EST90625 antibody; FLJ16381 antibody; KIAA1888 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ATP-binding cassette sub-family A member 5 protein (1230-1355AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ABCA5 Antibody (CSB-PA845163LA01HU)，的标记方式是Non-conjugated。对于ABCA5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA845163LB01HU ABCA5 Antibody, HRP conjugated ELISA
    FITC CSB-PA845163LC01HU ABCA5 Antibody, FITC conjugated
    Biotin CSB-PA845163LD01HU ABCA5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.
  • 基因功能参考文献：
    1. This report represents the first extensive expression and functional study of ABCA5 in the human brain and our data suggest a plausible function of ABCA5 in the brain as a cholesterol transporter associated with Abeta generation PMID: 25125465
    2. our findings support ABCA5 as a gene underlying the congenital generalized hypertrichosis terminalis phenotype and suggest a novel, previously unrecognized role for this gene in regulating hair growth. PMID: 24831815
    3. The expression of ABCA5 was significantly elevated in parkinson disease brains compared to age- and gender-matched control brains. PMID: 23939407
    4. The ABCB5 gene may be related to the properties of chemoresistance and aggressiveness of melanoma PMID: 20487690
    5. Cloning of ABCA5 and detection of a splice variant. PMID: 12504089
    6. ABCA5 may have a role in prostatic intraepithelial neoplasia PMID: 17289887
    7. There is a correlation of induction of ABCA5 and mRNA with differentiation of colonic neoplasms. PMID: 17541169

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  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane.
  • 蛋白家族：
    ABC transporter superfamily, ABCA family
  • 组织特异性：
    Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath. Expre
  • 数据库链接：

    HGNC: 35

    OMIM: 612503

    KEGG: hsa:23461

    STRING: 9606.ENSP00000376443

    UniGene: Hs.731824