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ABCA13 Antibody

  • 货号：
    CSB-PA007525
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q86UQ4
  • 基因名：
  • 别名：
    Abca13 antibody; ABCAD_HUMAN antibody; ATP-binding cassette sub-family A member 13 antibody; FLJ33876 antibody; FLJ33951 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ABCA13.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons.
  • 基因功能参考文献：
    1. ABCA13 gene may contain overlapping common genetic risk factors for both major depressive disorder and schizophrenia in the Han Chinese population. PMID: 27712136
    2. Rare missense variants within a single gene, abca13, form yin yang haplotypes. PMID: 25898927
    3. The results of this study demonstrated that common genetic variants at ABCA13 are unlikely to be related to the pathogenesis of schizophrenia in the Han Chinese population. PMID: 23910238
    4. No copy number variation including ABCA13 was identified in schizophrenia, bipolar disorder, or major depressive disorder samples, nor in the controls. PMID: 23250005
    5. An alternative human ABCA13 transcript and protein. PMID: 23266639
    6. ABCA13 is a candidate gene in schizophrenia, bipolar disorder, and depression PMID: 19944402
    7. Description of a new gene that maps to chromosome 7. PMID: 12697998

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  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily
  • 组织特异性：
    Significantly expressed in the bone marrow, trachea, testis, thyroid and lung as well as in skin fibroblasts.
  • 数据库链接：

    HGNC: 14638

    OMIM: 607807

    KEGG: hsa:154664

    STRING: 9606.ENSP00000411096

    UniGene: Hs.226568