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Sdc1 Monoclonal Antibody

  • 货号：
    CSB-MA0208881A0m
  • 规格：
    ￥1320
  • 其他：

产品详情

  • 产品名称：
    mouse anti-Rattus norvegicus (Rat) Sdc1 monoclonal antibody
  • Uniprot No.：
    P26260
  • 基因名：
  • 别名：
    Sdc1 antibody; Synd1 antibody; Syndecan-1 antibody; SYND1 antibody; CD antigen CD138 antibody
  • 宿主：
    mouse
  • 反应种属：
    Rat
  • 免疫原：
    Recombinant Rat Syndecan-1 protein
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    monoclonal
  • 抗体亚型：
    IgG1
  • 纯化方式：
    >95%,protein G purifed
  • 克隆号：
    1B4F4
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
  • 基因功能参考文献：
    1. Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids. PMID: 27037369
    2. down-regulation of Syndecan-1 could inhibit VEGF-VEGFR-2 signaling through regulating internalization of VEGFR-2. PMID: 27075925
    3. expression upregulated two months after renal transplantation PMID: 25972509
    4. data suggest that after renal transplantation loss of hepatic HS together with increased syndecan-1 shedding hampers lipoprotein binding and uptake by the liver contributing to dyslipidemia PMID: 25154787
    5. analysis of the molecular events that drive endocytosis of syndecan-1, a raft-dependent receptor and identification of its novel endocytic motif, MKKK PMID: 23525115
    6. The abnormal expression of HSPG may be an important molecular mechanism that leads to the occurrence and development of proteinuria in adriamycin-induced nephropathy rats. PMID: 20506637
    7. role in regulatory mechanism of apoptosis PMID: 11979781
    8. Syndecan-1 mRNA expression is not modulated by FSH as it would result from the antagonistic effects of increased intracellular cAMP and intracellular calcium levels. PMID: 12135485
    9. The major injury-related change, seen in injured brain and cultured glia, was an increase in 2-O-sulphated HS and increased syndecan-1, suggesting novel approaches to modulating scar formation. PMID: 18279312

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular exosome.
  • 蛋白家族：
    Syndecan proteoglycan family
  • 数据库链接：

    KEGG: rno:25216

    STRING: 10116.ENSRNOP00000008582

    UniGene: Rn.11176