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PGC Monoclonal Antibody

  • 货号：
    CSB-MA112991A0m
  • 规格：
    ￥1320
  • 图片：
    • Immunohistochemical of paraffin-embedded human gastric cancer tissue using CSB-MA112991A0m at dilution of 1:200
  • 其他：

产品详情

  • 产品描述：

    The PGC monoclonal antibody is produced by immunizing mice with recombinant human PGC protein. B cells are isolated from the mouse spleen and fused with myeloma cells to generate hybridomas, from which the PGC antibody-generating hybridomas are selected out and cultured in the mouse abdominal cavity. The PGC monoclonal antibodies are obtained from the mouse ascites. This PGC monoclonal antibody is suitable for use in ELISA and IHC to detect human PGC proteins in various biological samples. It is purified using protein G affinity chromatography with a purity of over 95%.

    Progastricsin (PGC) is an inactive precursor of the enzyme pepsinogen, which is produced and secreted by the chief cells of the gastric glands in the stomach. It plays a crucial role in the digestive process, particularly in the stomach.

  • 产品名称：
    mouse anti-Homo sapiens (Human) PGC monoclonal antibody
  • Uniprot No.：
    P20142
  • 基因名：
    PGC
  • 别名：
    Gastricsin antibody; PEPC antibody; PEPC_HUMAN antibody; pepsin C antibody; Pepsinogen C antibody; pepsinogen group II antibody; PGC antibody; PGII antibody; preprogastricsin antibody; Progastricsin antibody
  • 宿主：
    mouse
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PGC
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    monoclonal
  • 抗体亚型：
    IgG1
  • 纯化方式：
    >95%,protein G purifed
  • 克隆号：
    1G1H3
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes a variety of proteins.
  • 基因功能参考文献：
    1. Recombinant pepsin C and pepsinogen C were purified from transgenic rice culture medium, and the NH2-terminal 5-residue sequences were verified by amino acid sequencing. PMID: 29108629
    2. serum levels correlated with age, sex and the level of Helicobacter pylori infection PMID: 27865295
    3. Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia. PMID: 26486507
    4. Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer. PMID: 25857852
    5. Data show that SNP interactions among H. pylori-related genes PGC, PTPN11, and IL1B, are associated with susceptibility to gastric carcinogenesis. PMID: 26158864
    6. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured.[Pepsinogen I, Gastrin 17] PMID: 22066020
    7. The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer. PMID: 25551587
    8. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication. PMID: 25028655
    9. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions. PMID: 24895149
    10. An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer. PMID: 24586594
    11. plasma PG II level significantly correlated with H. pylori-infected gastric cancer PMID: 23326145
    12. High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis. PMID: 24009139
    13. Levels of pepsinogen/pepsin A and C are higher in the mouth swabs of infants with clinical gastroesophageal reflux. PMID: 23311720
    14. PGC rs6458238, PGC rs4711690 and PTPN11 rs12229892 were associated with susceptibilities to atrophic gastritis and/or gastric cancer. PMID: 23455381
    15. Data suggest that serum pepsinogen I/II ratio (pepsinogen A/C ratio) is correlated with diabetic nephropathy and thus may be a biological marker for degree of urinary albumin excretion in patients with type 2 diabetes. PMID: 23047493
    16. The serum levels of PG II and G-17 were significantly higher in Changle than those in Fuan. PMID: 23117263
    17. Data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms. PMID: 23178618
    18. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured. PMID: 22066020
    19. Chinese patients with sPGII greater than 10.25 microg/L are at greater risk of various H. pylori-related gastropathies. PMID: 21303408
    20. PGC gene insertion/deletion polymorphism is negatively related to PGC protein expression in gastric mucosa, but is not related to the serum PGC level. PMID: 19624876
    21. Pepsinogen C insertion/deletion polymorphism and Helicobacter pylori infection seem to present a positive interaction in the development of gastric cancer. PMID: 19173902
    22. Pepsinogen C is expressed in a quarter of ovarian carcinomas and might identify a subset of patients with different prognosis PMID: 12128264
    23. These results suggest that there is some relation between pepsinogen C gene polymorphism and gastric cancer, and the person with homogenous allele 1 predisposes to gastric cancer more than those with other genotypes. PMID: 12508350
    24. results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach PMID: 12698190
    25. human cathelicidin antimicrobial peptide-18 in seminal plasma is processed to generate a 38-amino acid antimicrobial peptide ALL-38 by the prostate-derived protease gastricsin when incubated at a pH corresponding to the vaginal pH PMID: 12759353
    26. Pepsinogen C can be a good indicator in the screening and diagnosis of precursor of gastric cancer and gastric cancer. PMID: 15200883
    27. pepsinogen C may be expressed by uveal melanoma and suggest that this protein could be considered as a new, unfavorable prognostic factor in these tumors PMID: 15503827
    28. Higher levels of Pepsinogen II is associated with early gastric cancer PMID: 15688378
    29. pepsinogen C genetic variants have a role in gastric cancer PMID: 16937501
    30. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. PMID: 17559360
    31. pepsinogen C has a role in SP-B proteolytic processing in alveolar type 2 cells PMID: 18256027
    32. role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients PMID: 18447628
    33. pepsinogens may have a role in esophageal squamous dysplasia PMID: 18844222
    34. The pepsinogen C gene polymorphism increases an individual's susceptibility to gastric cancer and its precancerous conditions PMID: 19132389
    35. Decreased pepsinogen I/II ratio is a reliable marker for atrophy in the stomach corpus. PMID: 19731026

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase A1 family
  • 数据库链接：

    HGNC: 8890

    OMIM: 169740

    KEGG: hsa:5225

    STRING: 9606.ENSP00000362116

    UniGene: Hs.1867