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  4. Mouse BMP-binding endothelial regulator protein(BMPER) ELISA kit

Mouse BMP-binding endothelial regulator protein(BMPER) ELISA kit

  • 中文名称：
    小鼠BMP结合内皮调节因子(BMPER)酶联免疫试剂盒
  • 货号：
    CSB-EL002747MO
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Mouse BMPER ELISA Kit was designed for the quantitative measurement of Mouse BMPER protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 31.25 pg/mL-2000 pg/mL and the sensitivity is 7.81 pg/mL.

  • 别名：
    Bmper ELISA kit; Cv2BMP-binding endothelial regulator protein ELISA kit; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator ELISA kit; Protein crossveinless-2 ELISA kit; mCV2 ELISA kit
  • 缩写：
    BMPER
  • Uniprot No.：
  • 种属：
    Mus musculus (Mouse)
  • 样本类型：
    serum, plasma, tissue homogenates, cell lysates
  • 检测范围：
    31.25 pg/mL-2000 pg/mL
  • 灵敏度：
    7.81 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Cardiovascular
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
  • 基因功能参考文献：
    1. BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment. PMID: 29093060
    2. CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. PMID: 28464239
    3. BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response. PMID: 28596374
    4. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
    5. BMPER-induced BMP signaling promotes coronary artery remodeling. PMID: 24373957
    6. BMPER appears to play a role in regulating both vessel density and cardiac development PMID: 23200275
    7. BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin and epithelial leakage in vitro and in vivo. PMID: 23716395
    8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
    9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
    10. Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice. PMID: 22144676
    11. BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo. PMID: 21900199
    12. BMPER is important in the regulation of BMP signaling and revascularization in the hypoxic retina. PMID: 21737784
    13. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes. PMID: 20807528
    14. Cv2 enhances pro-BMP activity of Tsg. PMID: 19914233
    15. Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling. PMID: 15188429
    16. crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. PMID: 17035289
    17. The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. PMID: 18644438
    18. Cv2 may specify cardiac mesodermal lineage through inhibition of BMP signaling at early stage of cardiogenesis. PMID: 18662983
    19. Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. PMID: 18789316
    20. Study demonstrates that as molar concentrations of Bmper exceed Bmp4, Bmper dynamically switches from an activator to an inhibitor of Bmp4 signaling. PMID: 19221194

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：