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  4. Recombinant Mouse BMP-binding endothelial regulator protein (Bmper)

Recombinant Mouse BMP-binding endothelial regulator protein (Bmper)

  • 中文名称：
    Recombinant Mouse BMP-binding endothelial regulator protein(Bmper),Yeast
  • 货号：
    CSB-YP815887MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse BMP-binding endothelial regulator protein(Bmper),Yeast
  • 货号：
    CSB-EP815887MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse BMP-binding endothelial regulator protein(Bmper),Yeast
  • 货号：
    CSB-EP815887MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse BMP-binding endothelial regulator protein(Bmper),Yeast
  • 货号：
    CSB-BP815887MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse BMP-binding endothelial regulator protein(Bmper),Yeast
  • 货号：
    CSB-MP815887MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bmper
  • Uniprot No.：
  • 别名：
    Bmper; Cv2BMP-binding endothelial regulator protein; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Protein crossveinless-2; mCV2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    40-685
  • 氨基酸序列
    S SFLTGSVAKC ENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGA CCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCK NPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVR EVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGAS FVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDIKV CKFGSKIFRD GEMWSSVNCS ICACVKGKTE CRKKQCVPVS SCPQGKILNR KGCCPICTEK PGVCTVFGDP HYNTFDGRTF NFQGTCQYVL TKDCSSPASP FQVLVKNDAR RTRSFSWTKS VELMLGESTV SLQQHLTVRW NGSRIALPCH TPHFHIDLDG YLLKVTTRAG LEISWDGDSF VEVMAAPHLK GKLCGLCGNY NGHKRDDLIG GDGNFKFDVD DFAESWRVES NEFCNRPQRK PVPELCQGTV KVKLRAHREC QKLKSWEFQT CHSTVDYTTF YRSCVTDMCE CPVHKNCYCE SFLAYTRACQ REGIKVHWEP QQSCAATQCK HGAVYDTCGP GCVKTCDNWN EIGPCNKPCI AGCHCPANLV LHKGRCIKPV LCPQR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
  • 基因功能参考文献：
    1. BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment. PMID: 29093060
    2. CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. PMID: 28464239
    3. BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response. PMID: 28596374
    4. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
    5. BMPER-induced BMP signaling promotes coronary artery remodeling. PMID: 24373957
    6. BMPER appears to play a role in regulating both vessel density and cardiac development PMID: 23200275
    7. BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin and epithelial leakage in vitro and in vivo. PMID: 23716395
    8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
    9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
    10. Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice. PMID: 22144676
    11. BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo. PMID: 21900199
    12. BMPER is important in the regulation of BMP signaling and revascularization in the hypoxic retina. PMID: 21737784
    13. The data indicate a role for CV2 and Chd in the establishment of the vertebral morphogenetic field through the long-range relocalization of Chd/BMP complexes. PMID: 20807528
    14. Cv2 enhances pro-BMP activity of Tsg. PMID: 19914233
    15. Cv2 is a conserved, positive regulator of bone morphogenetic protein signaling. Its cysteine-rich domains acts as both positive and negative modulators of BMP signaling. PMID: 15188429
    16. crossveinless 2 has essential pro-Bmp functions for locally restricted signal enhancement in multiple aspects of mammalian organogenesis. PMID: 17035289
    17. The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. PMID: 18644438
    18. Cv2 may specify cardiac mesodermal lineage through inhibition of BMP signaling at early stage of cardiogenesis. PMID: 18662983
    19. Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. PMID: 18789316
    20. Study demonstrates that as molar concentrations of Bmper exceed Bmp4, Bmper dynamically switches from an activator to an inhibitor of Bmp4 signaling. PMID: 19221194

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:73230

    STRING: 10090.ENSMUSP00000071872

    UniGene: Mm.335020