Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3(ENPP3) ELISA kit
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中文名称:人膜外核苷酸焦磷酸酶/磷酸二酯酶家族成员3(ENPP3)酶联免疫试剂盒
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货号:CSB-EL007681HU
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:
This Human ENPP3 ELISA Kit was designed for the quantitative measurement of Human ENPP3 protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 0.156 ng/mL-10 ng/mL and the sensitivity is 0.039 ng/mL.
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别名:Alkaline phosphodiesterase I ELISA Kit; ARHR2 ELISA Kit; B10 ELISA Kit; CD203c ELISA Kit; CD203c antigen ELISA Kit; dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3) ELISA Kit; dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3) ELISA Kit; E NPP 3 ELISA Kit; E-NPP 3 ELISA Kit; Ectonucleotide pyrophosphatase/phosphodiesterase 3 ELISA Kit; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 ELISA Kit; ENPP3 ELISA Kit; ENPP3_HUMAN ELISA Kit; gp130RB13 6 ELISA Kit; gp130RB136 ELISA Kit; M6S1 ELISA Kit; NPP1 ELISA Kit; NPP3 ELISA Kit; NPPase ELISA Kit; NPPS ELISA Kit; Nucleotide pyrophosphatase ELISA Kit; PC 1 ELISA Kit; PC-1 ELISA Kit; PCA1 ELISA Kit; PD Ibeta ELISA Kit; PD-Ibeta ELISA Kit; PDNP1 ELISA Kit; PDNP3 ELISA Kit; Phosphodiesterase I beta ELISA Kit; Phosphodiesterase I/nucleotide pyrophosphatase 3 ELISA Kit; phosphodiesterase i/nucleotide pyrophosphatase beta ELISA Kit
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缩写:
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Uniprot No.:
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种属:Homo sapiens (Human)
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样本类型:serum, plasma, tissue homogenates, cell lysates
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检测范围:0.156 ng/mL-10 ng/mL
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灵敏度:0.039 ng/mL
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Epigenetics and Nuclear Signaling
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测定原理:quantitative
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测定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
线性度:
To assess the linearity of the assay, samples were spiked with high concentrations of human ENPP3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 97 Range % 93-101 1:2 Average % 99 Range % 92-105 1:4 Average % 89 Range % 83-94 1:8 Average % 91 Range % 87-96 -
回收率:
The recovery of human ENPP3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 104 98-109 EDTA plasma (n=4) 85 80-90 -
标准曲线:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. ng/ml OD1 OD2 Average Corrected 10 2.755 2.858 2.807 2.691 5 2.212 2.221 2.217 2.101 2.5 1.537 1.477 1.507 1.391 1.25 0.946 0.954 0.950 0.834 0.625 0.489 0.473 0.481 0.365 0.312 0.289 0.274 0.282 0.166 0.156 0.210 0.218 0.214 0.098 0 0.115 0.116 0.116 -
数据处理:
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货期:3-5 working days
相关产品
靶点详情
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功能:Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.
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基因功能参考文献:
- We showed the ability of the immunological marker CD203c to predict the clinical efficacy of sublingual immunotherapy on rhinitis subjects allergic to Parietaria. PMID: 29702283
- Basophil CD203c surface expression reliably discriminated cystic fibrosis with allergic bronchopulmonary aspergillosis from cystic fibrosis with Aspergillus colonization and cystic fibrosis over time. PMID: 26585435
- Expression of CD203c on basophils as a marker of immunoglobulin E-mediated (L)-asparaginase allergy. PMID: 23581640
- Anaphylactic transfusion reaction in homozygous haptoglobin deficiency detected by CD203c expression on basophils. PMID: 24497482
- ENPP3 is a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) PMID: 23960081
- The early signaling requirements for the CD11b/CD203c compartment expression and CD63 degranulation provide support for the hypothesis that CD11b and CD203c reside in a similar compartment. PMID: 22722613
- Subjects with nut allergy show an increase of basophil CD203c levels at baseline and following rapid ex vivo stimulation with nut allergen PMID: 20975283
- Asthma exacerbation was accompanied by increased expression of CD203c on basophils that decreased significantly during remission PMID: 20159259
- Influence of hyperosmotic conditions on basophil CD203c upregulation in patients with food-dependent exercise-induced anaphylaxis. PMID: 20047266
- Data show that low and high dilutions of histamine inhibit CD203c up-regulation in anti-IgE stimulated basophils. PMID: 19418203
- E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma PMID: 14533006
- E-NPP3 is involved in the infiltration of neoplastic bile duct carcinoma PMID: 15072822
- Our data demonstrate that leptin promotes platelet activation, provides a mechanistic basis for the prothrombotic effect of this hormone, and identifies a potentially novel therapeutic avenue to limit obesity-associated cardiovascular disease. PMID: 15886225
- In conclusion, using well-defined experimental conditions, the measurement of CD203c up-regulation on basophils in response to specific allergens is as reliable as CD63-BAT for the in vitro diagnosis of patients with IgE-mediated allergy. PMID: 17275019
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亚细胞定位:Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted.
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蛋白家族:Nucleotide pyrophosphatase/phosphodiesterase family
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组织特异性:Detected on bile ducts in liver, and in blood serum (at protein level). Detected in prostate and uterus. Detected on basophils, but not neutrophils.
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数据库链接:
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