Human A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1(ADAMTS1) ELISA kit

Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

1. we identified Adamts1 as the modulator of a potent pathway that converts changes in diet into a cellular signal in adipose tissue that controls APC activity in vivo PMID: 28700319
2. ADAMTS 1 may be necessary during the decidualization and implantation stages of early normal pregnancy. PMID: 28949770
3. Significant differences in gene expression profiles were observed between patients with post-kidney transplant bladder tumors and those with conventional bladder tumors. ADAMTS1 expression was significantly lower in first group than in the second. PMID: 29038419
4. Our study demonstrated that altered levels of ADAMTS-1 and aggrecan may have a partial role in the etiopathogenesis of Polycystic ovary syndrome (PCOS), and ADAMTS-1 could be a predictive marker for implantation success in PCOS patients. PMID: 28417352
5. Adamts1 acts as an extracellular matrix 'modifier', with miR-181d-induced downregulation, that regulates adipocyte lineage commitment and obesity. PMID: 27447109
6. This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer) PMID: 28814085
7. Taken together, our findings suggested that miR-362-3p inhibits the proliferation and migration of VSMCs by directly targeting ADAMTS1, which might provide novel insight into the molecular mechanisms underlying the action of miR-362-3p in atherosclerosis. PMID: 28890348
8. ADAMTS1 has diverse roles in angiogenesis, tumor microenvironment and lymphangiogenesis. PMID: 28674292
9. Patients with Marfan syndrome showed elevated NOS2 and decreased ADAMTS1 protein levels in the aorta. PMID: 28067899
10. Data indicate that serum versican levels were significantly decreased in polycystic ovary syndrome (PCOS) patients, and that serum ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) and versican levels were significantly and positively correlated with each other. PMID: 27908842
11. Findings indicate that ADAMTS-1 has proteolytic functions in the nucleus through its interaction with aggrecan substrate in normal and tumoral breast cells. PMID: 27764205
12. implicated in knee destruction in Kashin-Beck disease PMID: 27053287
13. All ADAMTS tested in our study were expressed in both stable and unstable carotid plaques, especially in smooth muscle cells and macrophages. Analysis of the expression pattern on mRNA level showed significant higher expression of ADAMTS1 in unstable plaques compared with stable plaques. PMID: 25689086
14. ADAMTS1 protein levels in semen were significantly lower in males with infertility. Sperm count and motility showed a negative correlation with levels of ADAMTS1 protein expression. PMID: 26888488
15. increased expression of ADAMTS1 protein in macrophages and neutrophils that infiltrated aortic tissues may promote the progression of acute aortic dissection PMID: 26563155
16. High ADAMTS1 expression was significantly associated with tumorigenicity of Kaposi's sarcoma-associated herpesvirus infected endothelial cells. PMID: 26675551
17. Data suggest that the rs416905 and rs402007 single nucleotide polymorphisms of the a disintegrin and metallo-proteinase with thrombospondin type 1 motifs (ADAMTS-1) gene may be associated with ischemic stroke caused by large artery atherosclerosis (LAA). PMID: 26663063
18. Results show that ADAMTS1 expression is negatively regulated in breast neoplasm cells due to mir-365 targeting its 3'UTR. PMID: 25998153
19. The aberrant methylation of ADAMTS1 may be involved in the development and progression of gastric cancer. PMID: 25936341
20. Ectopic expression of SP1 and USF transcription factors resulted in the decrease in ADAMTS1 transcriptional activity of all promoter constructs PMID: 26299656
21. single-nucleotide missense mutation in the ADAMTS1 gene (c. 742I>T) was found to segregate in the family, given that the affected individuals must be heterozygous for the mutation PMID: 26124221
22. Dysregulated expression of ADAMTS-1 in polycystic ovary syndrome may influence oocyte quality-via Granulosa cells-oocyte paracrine and endocrine mechanism. PMID: 24646063
23. ADAMTS1 formed a complex with VEGFC, attenuated VEGFR3 phosphorylation and inhibited lymphangiogenesis in vitro. PMID: 24631293
24. ADAMTS1 expression is decreased in breast tumor specimens. PMID: 23681936
25. ADAMTS-1 expression was decreased in human breast tumors, and ADAMTS-1 knockdown stimulated migration, invasion and invadopodia formation in breast cancer cells in vitro. PMID: 23289900
26. These findings suggest that ADAMTS1 expression is altered in primary gastric cancer and paired lymph node metastasis and has angioinhibitory effects. PMID: 23001403
27. our results demonstrated that ADAMTS1 gene transfer inhibited angiogenesis in vitro and in vivo PMID: 22776012
28. Pericyte-derived TIMP3 stabilized and ADAMTS1 destabilized the capillary tubular networks PMID: 22383695
29. ADAMTS-1 was present in human coronary atherosclerotic plaques; ADAMDTS-1 was differentially expressed between acute myocardial infarction and stable angina; and ADAMTS-1 immunopositive cells were mainly macrophages. PMID: 21345877
30. AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo. PMID: 20795945
31. The correlation between its expression in cumulus granulosa cells and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function PMID: 20655981
32. ADAMTS1 expression is elevated in endometrial adenocarcinoma PMID: 20840749
33. ADAMTS1 is an important regulatory factor of angiogenesis and tumor growth in prostate tumors, where modified ADAMTS1 expression resulted in markedly changed blood vessel morphology, possibly related to altered thrombospondin 1 levels. PMID: 20546609
34. Study documents the expression of ADAMTS1 in aggressive and highly plastic melanoma and Ewing sarcoma cells. Inhibiting ADAMTS1 compromised the endothelial mimetic attributes observed. PMID: 20484033
35. results indicate that the antiangiogenic activity of TSP1 is differentially regulated by ADAMTS1 in the liver and lung, emphasizing the concept that regulation of angiogenesis is varied in different tissue environments. PMID: 20103648
36. cleavage of semaphorin 3C induced by ADAMTS1 promotes the migration of breast cancer cells, indicating that the co-expression of these molecules in tumors may contribute to the metastatic program PMID: 19915008
37. properties investigated through protein engineering PMID: 12054626
38. cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors PMID: 12054629
39. ADAMTS-1 is the first matrix-degrading enzyme downregulated by the catabolic factor IL-1beta in vitro. PMID: 14760803
40. ADAMTS-1 expression was significantly reduced in the presence of HDL subfraction 3. PMID: 14996435
41. results suggest that conserved residues other than the furin cleavage site in the prodomain of a disintegrin and metalloprotease with thrombospondin type I motif(ADAMTS-1) are involved in its biosynthesis PMID: 15184385
42. negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer PMID: 15599946
43. ADAMTS-1-immunoreactivity was manifold increased in brain with Down syndrome and neurodegeneration. PMID: 15661359
44. specific distribution pattern of ADAMTS-1 in a variety of organs during embryogenesis suggests a role of the molecule in tissue remodelling, vasculogenesis and angiogenesis PMID: 15878613
45. Expression of ADAMTS1 was downregulated by cAMP in normal, but not in SV40-transformed cells, suggesting that in normal cells epiregulin and amphiregulin activity is downregulated by a feedback mechanism that may be lost in SV40-transformed cells PMID: 15967414
46. fibulin-1 is a new regulator of ADAMTS-1-mediated proteoglycan proteolysis and may play an important role in proteoglycan turnover in tissues where there is overlapping expression PMID: 16061471
47. Overexpression of ADAMTS-1 promotes pulmonary metastasis of mammary carcinoma and Lewis lung carcinoma cells and that a proteinase-dead mutant of ADAMTS-1 inhibits their metastasis PMID: 16314835
48. Has a previously unreported gelatinolytic activity. PMID: 16328961
49. ADAMTS-1 expression is associated with decidualization of the endometrial stroma in vivo. IL-1beta increased whereas TGF-beta1 decreased ADAMTS-1 mRNA and protein levels in decidual stromal cell cultures in a concentration- and time-dependent manner. PMID: 16675485
50. Hypermethylation was subsequently identified for three of four analyzed genes, ADAMTS1 (85%), CRABP1 (90%), and NR3C1 (35%). PMID: 17167179

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Secreted, extracellular space, extracellular matrix.

HGNC: 217

OMIM: 605174

KEGG: hsa:9510

STRING: 9606.ENSP00000284984

UniGene: Hs.643357