cdk4

CDK4，即细胞周期蛋白依赖性激酶4，别名P15INK4B结合伴侣、P16INK4A结合伴侣、CDKN2A/p16INK4a互作伴侣等。它是一种由CDK4基因编码的丝氨酸/苏氨酸激酶，属于细胞周期调控蛋白家族成员。CDK4在细胞周期的G1期向S期转换中发挥关键作用，主要通过与周期蛋白D（cyclin D）形成复合体，磷酸化视网膜母细胞瘤蛋白（Rb），从而促进Rb蛋白的去磷酸化，释放E2F家族转录因子，推动细胞周期进程。CDK4在生物学上的意义非常广泛，它参与调控细胞周期、细胞增殖、分化和衰老等重要生物学过程。CDK4的活性受到多种因素的精细调控，包括周期蛋白的合成、降解以及CDK抑制因子（CKIs）的抑制作用。CDK4的功能异常与多种疾病有关，尤其是与肿瘤的发生发展密切相关。例如，在多种肿瘤中观察到CDK4的过表达或Rb蛋白功能丧失，导致细胞周期失控和肿瘤细胞的无限制增殖。因此，CDK4是肿瘤治疗中的一个潜在靶点，针对CDK4的小分子抑制剂正在被开发用于治疗某些类型的癌症。

热销产品

Recombinant Human Cyclin-dependent kinase 4 (CDK4) (CSB-EP005065HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CDK4 Recombinant Monoclonal Antibody (CSB-RA965615A0HU)

验证数据

Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
All lanes: CDK4 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 34, 21 kDa
Observed band size: 34 kDa

Immunoprecipitating CDK4 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-RA965615A0HU in Hela whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/1500)
Lane 2:CSB-RA965615A0HU(2µg)+ Hela whole cell lysate(500µg)
Lane 3: Hela whole cell lysate (10µg)

cdk4 Antibody

cdk4 Protein

cdk4 ELISA Kit

cdk4 Antibodies

cdk4 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA005065GA01HU	CDK4 Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA11659D0Rb	CDK4 Antibody, Biotin conjugated	Human	ELISA
CSB-PA11659B0Rb	CDK4 Antibody, HRP conjugated	Human	ELISA
CSB-PA11659C0Rb	CDK4 Antibody, FITC conjugated	Human
CSB-PA11659A0Rb	CDK4 Antibody	Human	ELISA, IHC
CSB-PA275368	CDK4 Antibody	Human	ELISA,WB,IHC
CSB-PA005118	CDK4 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA597701	CDK4 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-RA965615A0HU	CDK4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IP
CSB-RA697694A0HU	CDK4 Recombinant Monoclonal Antibody	Human	ELISA, WB

cdk4 Proteins

cdk4 Proteins for Sus scrofa (Pig)

产品货号	产品名称	来源
CSB-YP005065PI CSB-EP005065PI CSB-BP005065PI CSB-MP005065PI CSB-EP005065PI-B	Recombinant Pig Cyclin-dependent kinase 4 (CDK4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

cdk4 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP005065HU CSB-MP005065HU CSB-EP005065HU-B	Recombinant Human Cyclin-dependent kinase 4 (CDK4)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP005065HU	Recombinant Human Cyclin-dependent kinase 4 (CDK4)	E.coli

cdk4 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP005065MO CSB-EP005065MO CSB-BP005065MO CSB-MP005065MO CSB-EP005065MO-B	Recombinant Mouse Cyclin-dependent kinase 4 (Cdk4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

cdk4 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP005065RA CSB-EP005065RA CSB-BP005065RA CSB-MP005065RA CSB-EP005065RA-B	Recombinant Rat Cyclin-dependent kinase 4 (Cdk4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

cdk4 Proteins for Xenopus laevis (African clawed frog)

产品货号	产品名称	来源
CSB-YP005065XBE CSB-EP005065XBE CSB-BP005065XBE CSB-MP005065XBE CSB-EP005065XBE-B	Recombinant Xenopus laevis Cyclin-dependent kinase 4 (cdk4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

cdk4 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP005065BO CSB-EP005065BO CSB-BP005065BO CSB-MP005065BO CSB-EP005065BO-B	Recombinant Bovine Cyclin-dependent kinase 4 (CDK4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli