c5ar1
C5AR1：补体系统潜力分子，有望助力新型冠状病毒（COVID-19）治疗！
C5AR1（C5a过敏毒素趋化受体，C5a-R或CD88）是一种经典的G蛋白偶联受体。C5AR1又称为补体片段C5a受体，在先天性免疫反应中起着关键作用。作为补体系统的一部分，补体通路产生的补体C5a分子与其受体C5AR1结合，激活C5AR1-C5a轴。C5AR1与C5a互相作用，进而发挥促炎作用。C5AR1主要在粒细胞、单核细胞、树突状细胞和多种肿瘤组织中的MDSCs（骨髓源性抑制细胞）上表达。大量研究表明，靶向此过程可治疗多种相关疾病，包括慢性肾脏疾病，心血管疾病，神经系统疾病，以及癌症等。更重要的是，Nature报道的一项研究证实，重症COVID-19与全身炎症反应相关，患者机体出现炎症和凝血，并伴随肺和肾脏损伤。这项研究提供了COVID-19重要的生物标记物和潜在治疗方法。尤其是针对正在进行的补体抑制剂治疗COVID-19的研究，提供了一个新治疗靶点。
CUSABIO-哺乳包膜VLPs平台成功开发C5AR1全长膜蛋白（7次跨膜），展示了完整生物活性。
热销产品
Recombinant Human C5a anaphylatoxin chemotactic receptor 1(C5AR1)-VLPs (Active)(CSB-MP003996HU)
CSB-MP003996HU is detected by Mouse anti-6*His monoclonal antibody.
Immobilized human C5AR1 at 10 μg/ml can bind anti-C5AR1 recombinant antibody (CSB-RA003996A0HU). The EC50 is 1.239-3.760 ng/mL.
by TEM
The presence of VLP-like structures was confirmed by TEM.
c5ar1 Antibodies
c5ar1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA003996GA01HU | C5AR1 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA001479 | C5AR1 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA060025 | Phospho-C5AR1 (S338) Antibody | Human | IHC, ELISA |
| CSB-PA003996LA01HU | C5AR1 Antibody | Human | ELISA, WB, IF |
| CSB-RA003996A0HU | C5AR1 Recombinant Monoclonal Antibody | Human | ELISA |
c5ar1 Proteins
c5ar1 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996MOW1 CSB-EP003996MOW1 CSB-BP003996MOW1 CSB-MP003996MOW1 CSB-EP003996MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996MOW | Recombinant Macaca mulatta (Rhesus macaque) C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
c5ar1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996HU1 CSB-BP003996HU1 CSB-MP003996HU1 |
Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast Baculovirus Mammalian cell |
| CSB-CF003996HUd7 | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
| CSB-MP003996HU | Recombinant Human C5a anaphylatoxin chemotactic receptor 1 (C5AR1)-VLPs (Active) | Mammalian cell |
c5ar1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996DO1 CSB-EP003996DO1 CSB-BP003996DO1 CSB-MP003996DO1 CSB-EP003996DO1-B |
Recombinant Dog C5a anaphylatoxin chemotactic receptor 1 (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996DO | Recombinant Dog C5a anaphylatoxin chemotactic receptor 1 (C5AR1) | in vitro E.coli expression system |
c5ar1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996MO1 CSB-BP003996MO1 CSB-MP003996MO1 |
Recombinant Mouse C5a anaphylatoxin chemotactic receptor (C5ar1), partial | Yeast Baculovirus Mammalian cell |
| CSB-CF003996MO | Recombinant Mouse C5a anaphylatoxin chemotactic receptor (C5ar1) | in vitro E.coli expression system |
c5ar1 Proteins for Cavia porcellus (Guinea pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996GU1 CSB-EP003996GU1 CSB-BP003996GU1 CSB-MP003996GU1 CSB-EP003996GU1-B |
Recombinant Guinea pig C5a anaphylatoxin chemotactic receptor 1 (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996GU | Recombinant Guinea pig C5a anaphylatoxin chemotactic receptor 1 (C5AR1) | in vitro E.coli expression system |
c5ar1 Proteins for Pongo pygmaeus (Bornean orangutan)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996EXP1 CSB-EP003996EXP1 CSB-BP003996EXP1 CSB-MP003996EXP1 CSB-EP003996EXP1-B |
Recombinant Pongo pygmaeus C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996EXP | Recombinant Pongo pygmaeus C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
c5ar1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996GGZ1 CSB-EP003996GGZ1 CSB-BP003996GGZ1 CSB-MP003996GGZ1 CSB-EP003996GGZ1-B |
Recombinant Gorilla gorilla gorilla C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996GGZ | Recombinant Gorilla gorilla gorilla C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
c5ar1 Proteins for Pan troglodytes (Chimpanzee)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996EQV1 CSB-EP003996EQV1 CSB-BP003996EQV1 CSB-MP003996EQV1 CSB-EP003996EQV1-B |
Recombinant Pan troglodytes C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996EQV | Recombinant Pan troglodytes C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
c5ar1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996RA1 CSB-EP003996RA1 CSB-BP003996RA1 CSB-MP003996RA1 CSB-EP003996RA1-B |
Recombinant Rat C5a anaphylatoxin chemotactic receptor (C5ar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996RA | Recombinant Rat C5a anaphylatoxin chemotactic receptor (C5ar1) | in vitro E.coli expression system |
c5ar1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP003996DIL1 CSB-EP003996DIL1 CSB-BP003996DIL1 CSB-MP003996DIL1 CSB-EP003996DIL1-B |
Recombinant Danio rerio C5a anaphylatoxin chemotactic receptor (c5ar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF003996DIL | Recombinant Danio rerio C5a anaphylatoxin chemotactic receptor (c5ar1) | in vitro E.coli expression system |
c5ar1 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP747619OEI1 CSB-EP747619OEI1 CSB-BP747619OEI1 CSB-MP747619OEI1 CSB-EP747619OEI1-B |
Recombinant Oncorhynchus mykiss C5a anaphylatoxin chemotactic receptor (c5ar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF747619OEI | Recombinant Oncorhynchus mykiss C5a anaphylatoxin chemotactic receptor (c5ar1) | in vitro E.coli expression system |
c5ar1 Proteins for Oryctolagus cuniculus (Rabbit)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP874687RB1 CSB-EP874687RB1 CSB-BP874687RB1 CSB-MP874687RB1 CSB-EP874687RB1-B |
Recombinant Rabbit C5a anaphylatoxin chemotactic receptor (C5AR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF874687RB | Recombinant Rabbit C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system |
