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acvr2b

ACVR2B,即激活素A型II型受体B,它是一种由ACVR2B基因编码的跨膜丝氨酸/苏氨酸激酶受体,属于TGF-β超家族成员之一。ACVR2B在多种组织中表达,尤其在肿瘤细胞上的表达水平较高。其作用机制涉及与激活素A结合后,招募并磷酸化I型激活素受体,通过SMAD2/3蛋白发出信号,进而调节细胞的增殖、分化和迁移。ACVR2B参与的信号通路包括与ALK4或ALK7等I型受体的相互作用,影响多种生物学过程。在生物学意义上,ACVR2B的表达水平与肿瘤生长、转移性以及治疗反应密切相关,是肿瘤治疗和预后评估的重要生物标志物。

热销产品

Recombinant Human Activin receptor type-2B (ACVR2B), partial (CSB-YP623829HU)

验证数据

CSB-YP623829HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ACVR2B Recombinant Monoclonal Antibody (CSB-RA260702A0HU)

验证数据

CSB-RA260702A0HU

IHC image of CSB-RA260702A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA260702A0HU

IHC image of CSB-RA260702A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

acvr2b Antibodies

acvr2b for Homo sapiens (Human)

acvr2b Proteins

acvr2b Proteins for Mus musculus (Mouse)

acvr2b Proteins for Rattus norvegicus (Rat)

acvr2b Proteins for Xenopus laevis (African clawed frog)

acvr2b Proteins for Homo sapiens (Human)

acvr2b Proteins for Sus scrofa (Pig)

acvr2b Proteins for Gallus gallus (Chicken)

acvr2b Proteins for Bos taurus (Bovine)