XPO1
XPO1，即染色体区域维持1蛋白（Chromosome Region Maintenance 1 Protein），也被称为出口蛋白1（Exportin 1），是一种在细胞核输出过程中发挥关键作用的蛋白质。它通过识别并结合含有核输出信号的货物，如某些RNA和蛋白质，将它们从细胞核运输到细胞质中。XPO1的来源是细胞自身的基因编码，它在细胞分裂、基因表达调控、细胞信号传递等方面发挥着重要作用。其作用机制涉及到与Ran GTPase蛋白的相互作用，以及与货物蛋白的结合和释放，从而实现物质的定向运输。XPO1在生物学上的意义非常广泛，它涉及到细胞内多种信号通路的调控，包括但不限于p53信号通路、NF-κB信号通路等，这些信号通路与细胞的生长、分化、凋亡以及对外界刺激的响应密切相关。XPO1的功能异常与多种疾病相关，特别是在癌症中，XPO1的过表达与肿瘤的侵袭性、转移和化疗抵抗性有关。因此，XPO1成为了抗癌药物开发的重要靶点，通过抑制XPO1的活性，可以阻止肿瘤相关蛋白的核输出，进而影响肿瘤细胞的生长和存活。
热销产品
XPO1 Recombinant Monoclonal Antibody (CSB-RA930964A0HU)
验证数据
IHC image of CSB-RA930964A0HU diluted at 1:100 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA930964A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
XPO1 Antibodies
XPO1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA026221GA01HU | XPO1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000147 | Acetyl-XPO1 (K568) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA360041 | XPO1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA026221LA01HU | XPO1 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA026221LB01HU | XPO1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA026221LC01HU | XPO1 Antibody, FITC conjugated | Human | |
| CSB-PA026221LD01HU | XPO1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA930964A0HU | XPO1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
XPO1 Proteins
XPO1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP026221HU CSB-EP026221HU CSB-BP026221HU CSB-MP026221HU CSB-EP026221HU-B |
Recombinant Human Exportin-1 (XPO1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP026221SXV CSB-EP026221SXV CSB-BP026221SXV CSB-MP026221SXV CSB-EP026221SXV-B |
Recombinant Schizosaccharomyces pombe Exportin-1 (xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Dictyostelium discoideum (Slime mold)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP706698DKK CSB-EP706698DKK CSB-BP706698DKK CSB-MP706698DKK CSB-EP706698DKK-B |
Recombinant Dictyostelium discoideum Exportin-1 (xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP750809MO CSB-EP750809MO CSB-BP750809MO CSB-MP750809MO CSB-EP750809MO-B |
Recombinant Mouse Exportin-1 (Xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
XPO1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP802224RA CSB-EP802224RA CSB-BP802224RA CSB-MP802224RA CSB-EP802224RA-B |
Recombinant Rat Exportin-1 (Xpo1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
