WRN
WRN，即Werner综合征蛋白，它是一种多功能的DNA解旋酶，属于RecQ解旋酶家族的一员。WRN在细胞核中发挥作用，具有依赖于ATP的DNA解旋酶活性和3'端到5'端的外切酶活性。它的作用机制涉及到DNA复制、重组、损伤修复以及端粒的维护。WRN通过参与细胞周期调控和DNA修复信号通路，如与p53、RAD50、RAD51等蛋白相互作用，调节细胞对DNA损伤的响应。WRN的生物学意义在于维持基因组的完整性和稳定性，防止早衰和某些类型的癌症。WRN基因的突变与Werner综合征相关，这是一种早老性疾病，患者会经历加速的衰老过程和较高的癌症风险。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
WRN Antibodies
WRN for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA060086 | Phospho-WRN (S1141) Antibody | Human | WB, ELISA |
WRN Proteins
WRN Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP614518HU CSB-EP614518HU CSB-BP614518HU CSB-MP614518HU CSB-EP614518HU-B |
Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP614518HU1 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-EP614518HU1a0 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-EP614518HU1d8 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | E.coli |
| CSB-BP614518HU3 | Recombinant Human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (WRN), partial | Baculovirus |
