Tslp
TSLP（胸腺基质淋巴细胞生成素）是一种多效性细胞因子，属于短链四α螺旋束Ⅰ型IL-2家族，由上皮细胞产生，对免疫系统激活具有重要作用。TSLP通过与其受体复合物相互作用来发挥作用，该受体复合物由TSLP受体（TSLPR）和白细胞介素7受体α链（IL-7Rα）组成，进而激活下游的信号通路。TSLP有两种亚型，长亚型（lfTSLP）和短亚型（sfTSLP），分别由159个和63个氨基酸组成，与炎症作用和TSLP的稳态功能有关。TSLP的信号传导通过激活JAK-STAT5和PI3K-AKT通路，对多种免疫细胞的成熟和活化至关重要，包括树突状细胞和固有淋巴样细胞2（ILC2）。TSLP在过敏性疾病如哮喘、特应性皮炎、食物过敏、过敏性鼻炎、慢性阻塞性肺病等的发生和发展中发挥关键作用，并且其在癌症领域也显示出潜在作用，如抑制乳腺肿瘤的生长和转移。因此，TSLP是治疗过敏性疾病和某些癌症的潜在靶点，其信号通路的调节对于控制炎症和免疫反应具有重要意义。
热销产品
TSLP Antibody (CSB-PA025141LA01HU)
验证数据
Western Blot
Positive WB detected in: U87 whole cell lysate, SH-SY5Y whole cell lysate, Mouse liver tissue
All lanes: TSLP antibody at 3.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 19, 8 kDa
Observed band size: 19 kDa
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA025141LA01HU at dilution of 1:100
Tslp Antibodies
Tslp for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA025141GA01HU | TSLP Antibody | Human | ELISA,IHC |
| CSB-PA218260 | TSLP Antibody | Human | ELISA,WB |
| CSB-PA025141LA01HU | TSLP Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA025141LC01HU | TSLP Antibody, FITC conjugated | Human | |
| CSB-PA025141LD01HU | TSLP Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA025141A1HU | TSLP Monoclonal Antibody | Human | ELISA |
Tslp Proteins
Tslp Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025141HU CSB-BP025141HU CSB-EP025141HU-B |
Recombinant Human Thymic stromal lymphopoietin (TSLP) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002121HU | Recombinant Human Thymic stromal lymphopoietin protein (TSLP) | E.Coli |
| CSB-MP025141HU | Recombinant Human Thymic stromal lymphopoietin (TSLP) | Mammalian cell |
| CSB-EP025141HU | Recombinant Human Thymic stromal lymphopoietin (TSLP) | E.coli |
| CSB-MP025141HUh8(M) | Recombinant Human Thymic stromal lymphopoietin (TSLP)(R127A,R130A) | Mammalian cell |
| CSB-MP025141HU(M) | Recombinant Human Thymic stromal lymphopoietin (TSLP) (R127A,R130A) | Mammalian cell |
| CSB-MP025141HU(M) | Recombinant Human Thymic stromal lymphopoietin (TSLP) (R127A,R130A) | Mammalian cell |
Tslp Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025141MO CSB-EP025141MO CSB-BP025141MO CSB-MP025141MO CSB-EP025141MO-B |
Recombinant Mouse Thymic stromal lymphopoietin (Tslp) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Tslp ELISA Kit
Tslp ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E09316h | Human thymic stromal lymphopoietin,TSLP ELISA Kit | serum, plasma, tissue homogenates. | 0.078 ng/ml |
Tslp ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL025141MO | Mouse Thymic stromal lymphopoietin(TSLP) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/ml |
