Tnfrsf10b
TNFRSF10B，即肿瘤坏死因子受体超家族成员10B，也称为死亡受体5（DR5）。它是一种主要在多种组织中表达的细胞表面受体，尤其在肿瘤细胞中表达水平较高。TNFRSF10B的作用机制是通过与肿瘤坏死因子相关的凋亡诱导配体（TRAIL）结合，触发细胞凋亡信号通路。其信号通路涉及TRAIL与TNFRSF10B结合后，死亡结构域（DD）的聚集，进而招募Fas相关死亡结构域蛋白（FADD）和启动caspase级联反应，特别是激活caspase-8，导致细胞程序性死亡。TNFRSF10B在调控细胞生存与死亡平衡中扮演关键角色，其在肿瘤细胞凋亡中的特异性作用使其成为癌症治疗的有希望的靶点，有助于开发新的靶向治疗策略，以增强肿瘤细胞对凋亡的敏感性。
热销产品
TNFRSF10B Antibody (CSB-PA08165A0Rb)
验证数据
Immunofluorescence staining of HepG2 cells with CSB-PA08165A0Rb at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Tnfrsf10b Antibodies
Tnfrsf10b for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023965GA01HU | TNFRSF10B Antibody | Human | ELISA,WB |
| CSB-PA018500 | TNFRSF10B Antibody | Human | ELISA,WB |
| CSB-PA08165A0Rb | TNFRSF10B Antibody | Human | ELISA, IF |
| CSB-PA08165B0Rb | TNFRSF10B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08165C0Rb | TNFRSF10B Antibody, FITC conjugated | Human | |
| CSB-PA08165D0Rb | TNFRSF10B Antibody, Biotin conjugated | Human | ELISA |
Tnfrsf10b Proteins
Tnfrsf10b Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023965HU1 CSB-EP023965HU1 CSB-BP023965HU1 CSB-MP023965HU1 CSB-EP023965HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP002291HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B),Partial (Active) | E.Coli |
| CSB-CF023965HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) | in vitro E.coli expression system |
| CSB-AP004921HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) | Mammalian cell |
| CSB-AP004931HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) | Mammalian cell |
Tnfrsf10b Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP886404MO CSB-EP886404MO CSB-BP886404MO CSB-MP886404MO CSB-EP886404MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 10B (Tnfrsf10b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP005041MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 10B (Tnfrsf10b), partial (Active) | Mammalian cell |
Tnfrsf10b ELISA Kit
Tnfrsf10b ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E13164h | Human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2(TRAIL-R2/DR5) ELISA Kit | serum, plasma | 7.8 pg/mL |
