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Tnf

TNF,即肿瘤坏死因子。TNF是一种主要由活化的巨噬细胞产生的重要细胞因子,属于多肽类激素。它在人体免疫系统中发挥着关键作用,尤其是在炎症反应和细胞凋亡的调控中。TNF的作用机制涉及与细胞表面的TNF受体(TNFR)结合,主要包括TNFR1和TNFR2两种类型。这种结合激活了多种下游信号通路,包括NF-κB、MAPK和JNK等,这些信号通路进一步调控细胞的存活、增殖、分化和死亡。TNF的生物学意义主要体现在其对炎症反应的调控和在免疫应答中的作用。作为炎症过程中的关键介质,TNF能够促进炎症细胞的聚集和活化,调节细胞因子的产生,以及影响血管的通透性。此外,TNF还参与调节细胞的凋亡过程,对肿瘤细胞具有抑制作用,这也是其名称中“肿瘤坏死因子”的由来。然而,TNF的过度表达或异常调节与多种疾病有关,包括自身免疫性疾病、慢性炎症和某些类型的癌症,因此,针对TNF的拮抗剂已成为治疗这些疾病的有效手段。

热销产品

Recombinant Human Tumor necrosis factor (TNF), partial (Active) (CSB-YP023955HU)

验证数据

CSB-YP023955HU

Activity
Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The EC50 for this effect is 33.32-47.38 pg/mL.

CSB-YP023955HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Tnf Antibodies

Tnf for Sheep

Tnf for Bovine

Tnf for Homo sapiens (Human)

Tnf for H,R,M

Tnf Proteins

Tnf Proteins for Bos taurus (Bovine)

Tnf Proteins for Capra hircus (Goat)

Tnf Proteins for Felis catus (Cat) (Felis silvestris catus)

Tnf Proteins for Sus scrofa (Pig)

Tnf Proteins for Equus caballus (Horse)

Tnf Proteins for Cavia porcellus (Guinea pig)

Tnf Proteins for Macaca mulatta (Rhesus macaque)

Tnf Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

Tnf Proteins for Mus musculus (Mouse)

Tnf Proteins for Oryctolagus cuniculus (Rabbit)

Tnf Proteins for Trichosurus vulpecula (Brush-tailed possum)

Tnf Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Tnf Proteins for Rattus norvegicus (Rat)

Tnf Proteins for Papio sp. (Baboon)

Tnf Proteins for Peromyscus leucopus (White-footed mouse)

Tnf Proteins for Cervus elaphus (Red deer)

Tnf Proteins for Bos indicus (Zebu)

Tnf Proteins for Bubalus bubalis (Domestic water buffalo)

Tnf Proteins for Lama glama (Llama)

Tnf Proteins for Papio anubis (Olive baboon)

Tnf Proteins for Marmota monax (Woodchuck)

Tnf Proteins for Papio hamadryas ursinus (Chacma baboon)

Tnf Proteins for Macropus eugenii (Tammar wallaby)

Tnf Proteins for Callithrix jacchus (White-tufted-ear marmoset)

Tnf Proteins for Boselaphus tragocamelus (Nilgai)

Tnf Proteins for Dasypus novemcinctus (Nine-banded armadillo)

Tnf Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)

Tnf Proteins for Tupaia tana (Large tree shrew)

Tnf Proteins for Camelus bactrianus (Bactrian camel)

Tnf Proteins for Pan troglodytes (Chimpanzee)

Tnf Proteins for Sparus aurata (Gilthead sea bream)

Tnf Proteins for Saimiri sciureus (Common squirrel monkey)

Tnf Proteins for Delphinapterus leucas (Beluga whale)

Tnf Proteins for Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)

Tnf Proteins for Ovis aries (Sheep)

Tnf Proteins for Homo sapiens (Human)

Tnf ELISA Kit

Tnf ELISA Kit for Bos taurus (Bovine)

Tnf ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

Tnf ELISA Kit for Capra hircus (Goat)

Tnf ELISA Kit for Guinea Sus scrofa (Pig)

Tnf ELISA Kit for Equus caballus (Horse)

Tnf ELISA Kit for Homo sapiens (Human)

Tnf ELISA Kit for Monkey

Tnf ELISA Kit for Mus musculus (Mouse)

Tnf ELISA Kit for Oryctolagus cuniculus (Rabbit)

Tnf ELISA Kit for Rattus norvegicus (Rat)

Tnf ELISA Kit for Ovis aries (Sheep)

Tnf ELISA Kit for Sus scrofa (Pig)