TNFSF18

TNFSF18（Tumor Necrosis Factor Superfamily Member 18），也被称为GITRL（Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand），是肿瘤坏死因子超家族中的一种蛋白质。它与其受体GITR相互作用，这个相互作用可以激活T细胞和其他免疫细胞，促进免疫反应。TNFSF18的结构包括一个细胞外域，用于与GITR结合，一个跨膜域，以及一个细胞内域，用于激活信号传导通路。TNFSF18/GITR信号通路对于调节T细胞的活性和功能具有重要影响，尤其在抗肿瘤免疫中起到了关键作用。TNFSF18的研究已引起在癌症治疗、自身免疫疾病治疗以及移植免疫学等领域的广泛兴趣。了解TNFSF18/GITR信号通路的调节可以帮助开发新的免疫治疗策略。

热销产品

Recombinant Human Tumor necrosis factor ligand superfamily member 18(TNFSF18),partial (Active) CSB-MP891791HU

验证数据

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized TNFRSF18 at 2 μg/ml can bind TNFSF18 (CSB-MP891791HU), the EC₅₀ is 2.565 to 2.940 ng/ml.

LSPR

Activity: Human TNFRSF18 protein hFc tag (CSB-MP896537HU) captured on COOH chip can bind Human TNFSF18 protein hFc and Flag tag (CSB-MP891791HU) with an affinity constant of 38.5 nM as detected by LSPR Assay.

TNFSF18 Antibody

TNFSF18 Protein

TNFSF18 ELISA Kit

TNFSF18 Antibodies

TNFSF18 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA891791ESR1HU	TNFSF18 Antibody	Human	ELISA, IHC

TNFSF18 Proteins

TNFSF18 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP749268MO CSB-EP749268MO CSB-BP749268MO CSB-MP749268MO CSB-EP749268MO-B	Recombinant Mouse Tumor necrosis factor ligand superfamily member 18 (Tnfsf18), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNFSF18 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP891791HU CSB-EP891791HU CSB-BP891791HU CSB-EP891791HU-B	Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-AP002351HU	Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18), partial (Active)	E.Coli
CSB-MP891791HU	Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), partial (Active)	Mammalian cell