Srd5a2
SRD5A2,即类固醇5α-还原酶2,别名3-氧-5α-类固醇4-脱氢酶2、II型5α-还原酶等。它是一种微粒体酶,主要在人体中由SRD5A2基因编码,高表达于对雄激素敏感的组织如前列腺。SRD5A2的作用机制是通过催化睾酮转化为双氢睾酮(DHT),DHT与毛囊雄激素受体结合能力更强,这一过程对于性分化和雄激素生理学具有重要作用。此外,SRD5A2还参与了其他类固醇激素的代谢过程。SRD5A2在生物学上的意义非常广泛,它不仅参与调节生殖系统的正常发育和功能,还与多种疾病相关。例如,SRD5A2基因的突变可导致男性假两性畸形,特别是假阴道性会阴型尿道下裂。此外,SRD5A2的活性改变与前列腺癌的发展有关,其异常表达可能促进前列腺癌的进展。在药物研究方面,SRD5A2抑制剂如非那雄胺和杜特列特等药物已广泛应用于治疗前列腺增生等疾病。因此,SRD5A2是性激素相关疾病研究和治疗中的一个重要靶点。
热销产品
Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial (CSB-EP022654HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2) ELISA kit (CSB-EL022654HU)
验证数据
货号:CSB-EL022654HU
规格:96T/48T
灵敏度:6 pg/mL
检测范围:12 pg/mL-2400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
Srd5a2 Proteins
Srd5a2 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP022654HU1 CSB-BP022654HU1 CSB-MP022654HU1 CSB-EP022654HU1-B |
Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF022654HU | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) | in vitro E.coli expression system |
CSB-EP022654HU1 | Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), partial | E.coli |
Srd5a2 ELISA Kit
Srd5a2 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL022654HU | Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2(SRD5A2) ELISA kit | serum, plasma, tissue homogenates | 6 pg/mL |