SLFN11
SLFN11，全称为Schlafen 11，是一种干扰素诱导的抗病毒限制因子，具有tRNA内切核糖核酸酶和DNA结合功能。它在复制应激期间被招募到停滞的复制叉，并可能不可逆地触发复制阻塞和细胞死亡。SLFN11的基因参与细胞在化疗后的细胞命运决定，并编码N-末端核糖核酸酶(RNase)结构域和C-末端解旋酶/ATP酶结构域。这些结构域对化疗反应的贡献仍有争议。SLFN11在循环肿瘤细胞中的动态表达可作为小细胞肺癌的液体生物标志物，其表达水平在接受铂类治疗的患者中较低，并且与临床反应相关。在预测对包括铂类药物和PARP抑制剂在内的多种药物引起的DNA损伤治疗的反应中，SLFN11是一个有前景的生物标志物。
热销产品
Recombinant Human Schlafen family member 11 (SLFN11), partial (CSB-EP021760HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SLFN11 Antibody (CSB-PA021760LA01HU)
验证数据
Western Blot
Positive WB detected in: Mouse skeletal muscle tissue
All lanes: SLFN11 antibody at 2.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 103 kDa
Observed band size: 103 kDa
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA021760LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA021760LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
SLFN11 Antibodies
SLFN11 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA021760LA01HU | SLFN11 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA021760LB01HU | SLFN11 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA021760LC01HU | SLFN11 Antibody, FITC conjugated | Human | |
| CSB-PA021760LD01HU | SLFN11 Antibody, Biotin conjugated | Human | ELISA |
SLFN11 Proteins
SLFN11 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021760HU CSB-EP021760HU CSB-BP021760HU CSB-MP021760HU CSB-EP021760HU-B |
Recombinant Human Schlafen family member 11 (SLFN11), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP021760HU1 | Recombinant Human Schlafen family member 11 (SLFN11), partial | E.coli |
| CSB-EP021760HU(A4) | Recombinant Human Schlafen family member 11 (SLFN11) | E.coli |
| CSB-BP021760HU(A4) | Recombinant Human Schlafen family member 11 (SLFN11) | Baculovirus |
