SIRT3

SIRT3，作为线粒体中的关键去乙酰化修饰酶，其结构包括一个催化区以及调节酶活性的N端和C端结构。它在细胞应激时转移到线粒体内并成熟，从而发挥其去乙酰化功能。SIRT3主要通过调节线粒体结构和功能，如激活长链脂酰辅酶A脱氢酶，在脂肪代谢中发挥重要作用。在信号通路方面，SIRT3通过调控GSK-3β/β-catenin信号通路来抑制NLRP3炎性小体的表达，从而保护骨骼成骨。同时，在肾脏疾病中，SIRT3通过去乙酰化作用抑制肾纤维化，并调控能量代谢稳态。此外，SIRT3还参与心脏氧化应激、缺血再灌注损伤等生理和病理过程。

热销产品

Recombinant Rat NAD-dependent protein deacetylase (Sirt3)

验证数据

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRT3 Antibody

SIRT3 Protein

SIRT3 ELISA Kit

SIRT3 Antibodies

SIRT3 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA882102ESR1HU	SIRT3 Antibody	Human	ELISA, WB, IHC
CSB-PA882102ESR2HU	SIRT3 Antibody	Human	ELISA, WB, IHC
CSB-PA229200	SIRT3 Antibody	Human	ELISA,WB
CSB-PA008365	SIRT3 Antibody	Human	WB, ELISA
CSB-PA100396	SIRT3 Antibody	Human,Mouse	ELISA,IHC
CSB-PA937428	SIRT3 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA882102LA01HU	SIRT3 Antibody	Human	ELISA, IF
CSB-PA882102LB01HU	SIRT3 Antibody, HRP conjugated	Human	ELISA
CSB-PA882102LD01HU	SIRT3 Antibody, Biotin conjugated	Human	ELISA

SIRT3 Proteins

SIRT3 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP882102HU CSB-EP882102HU CSB-BP882102HU CSB-MP882102HU CSB-EP882102HU-B	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP882102HU1	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3), partial	E.coli
CSB-EP882102HU1(M)	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) (R235A,E246A), partial	E.coli
CSB-EP882102HU2(M)	Recombinant Human NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) (R235A,E246A), partial	E.coli