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PLCD4

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 is a protein in humans that is encoded by PLCD4 gene. Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.

PLCD4 Antibodies

PLCD4 for Homo sapiens (Human)

PLCD4 Proteins

PLCD4 Proteins for Bos taurus (Bovine)

PLCD4 Proteins for Xenopus laevis (African clawed frog)

PLCD4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

PLCD4 Proteins for Rattus norvegicus (Rat)

PLCD4 Proteins for Pongo abelii (Sumatran orangutan)

PLCD4 Proteins for Mus musculus (Mouse)

PLCD4 Proteins for Sus scrofa (Pig)

PLCD4 Proteins for Homo sapiens (Human)