PLA2G10
PLA2G10（磷脂酶A2群X）是一种磷脂酶A2家族成员，具有催化磷脂SN-2酰基链水解的功能，释放出游离脂肪酸和溶血磷脂分子。它在细胞周期调控和免疫调节方面发挥作用，通过提高特定蛋白的表达水平，如在软组织平滑肌肉瘤细胞中提高cyclin E1/CDK2的表达，促进细胞周期进程。在肿瘤微环境中，PLA2G10与T细胞排斥有关，其高表达可能抑制T细胞浸润，影响肿瘤对免疫疗法的响应。此外，PLA2G10还参与甾体激素信号通路，作为孕酮受体的靶基因，在小鼠子宫中调节子宫接受性。PLA2G10的异常表达与多种疾病包括癌症和神经退行性疾病相关，其抑制或阻断可能有助于增强肿瘤对免疫疗法的敏感性，尤其是在对传统免疫检查点阻断疗法响应不佳的“冷肿瘤”中。因此，PLA2G10是一个有潜力的治疗靶点，其研究有助于开发新的癌症治疗策略。
热销产品
Recombinant Human Group 10 secretory phospholipase A2 (PLA2G10) (CSB-EP018085HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLA2G10 Antibodies
PLA2G10 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA018085LA01HU | PLA2G10 Antibody | Human | ELISA, IHC |
| CSB-PA018085LB01HU | PLA2G10 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018085LC01HU | PLA2G10 Antibody, FITC conjugated | Human | |
| CSB-PA018085LD01HU | PLA2G10 Antibody, Biotin conjugated | Human | ELISA |
PLA2G10 Proteins
PLA2G10 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018085HU CSB-BP018085HU CSB-MP018085HU CSB-EP018085HU-B |
Recombinant Human Group 10 secretory phospholipase A2 (PLA2G10) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018085HU | Recombinant Human Group 10 secretory phospholipase A2 (PLA2G10) | E.coli |
PLA2G10 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP874149RA CSB-BP874149RA CSB-MP874149RA CSB-EP874149RA-B |
Recombinant Rat Group 10 secretory phospholipase A2 (Pla2g10) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PLA2G10 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP882554MO CSB-MP882554MO CSB-EP882554MO-B |
Recombinant Mouse Group 10 secretory phospholipase A2 (Pla2g10) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP882554MO | Recombinant Mouse Group 10 secretory phospholipase A2 (Pla2g10) | E.coli |
| CSB-BP882554MO | Recombinant Mouse Group 10 secretory phospholipase A2 (Pla2g10) | Baculovirus |
