PARP1
PARP1（聚腺苷二磷酸核糖聚合酶1）是一种分子量为116 kDa的多功能酶，由三个主要结构域组成：DNA结合域、自身修饰域和催化域。PARP1在细胞内扮演着多种重要角色，包括DNA单链断裂修复、基因转录调控和细胞死亡调控。当DNA受损时，PARP1迅速被激活，通过形成PARP-DNA复合物来招募其他修复蛋白，参与碱基切除修复（BER）、非同源末端连接（NHEJ）和同源重组修复（HRR）等DNA修复途径。此外，PARP1通过ADP核糖化改变染色质结构和转录活性，与转录因子相互作用，调节基因表达。在严重DNA损伤情况下，PARP1的激活还会导致NAD+耗尽，引发细胞死亡。PARP1的活性受到诸如PTEN等抑癌基因的调控，并与ATM、BRCA1、BRCA2等蛋白相互作用，参与DNA损伤响应和细胞周期调控。PARP1抑制剂的开发已成为治疗特定类型癌症的重要策略，特别是在卵巢癌和乳腺癌的治疗中。
PARP1 Antibodies
PARP1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA017457GA01HU | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA010134 | Cleaved-PARP1 (A214) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA000059 | Cleaved-PARP1 (G215) Antibody | Human | WB, ELISA |
| CSB-PA000080 | Cleaved-PARP1 (D214) Antibody | Human,Mouse | WB, ELISA |
| CSB-PA966699 | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA436053 | PARP1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA405636 | PARP1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA890185 | Acetyl-PARP1 (K521) Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA017457LA01HU | PARP1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA017457LB01HU | PARP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017457LC01HU | PARP1 Antibody, FITC conjugated | Human | |
| CSB-PA017457LD01HU | PARP1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA160472A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA581794A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
| CSB-RA258431A0HU | PARP1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
PARP1 for H
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-MA000290 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
| CSB-MA000291 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
| CSB-MA000305 | PARP1 Monoclonal Antibody | Human | ELISA,WB |
PARP1 Proteins
PARP1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017457MO CSB-EP017457MO CSB-BP017457MO CSB-MP017457MO CSB-EP017457MO-B |
Recombinant Mouse Poly [ADP-ribose] polymerase 1 (Parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017457BO CSB-EP017457BO CSB-BP017457BO CSB-MP017457BO CSB-EP017457BO-B |
Recombinant Bovine Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017457CH CSB-EP017457CH CSB-BP017457CH CSB-MP017457CH CSB-EP017457CH-B |
Recombinant Chicken Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017457RA CSB-EP017457RA CSB-BP017457RA CSB-MP017457RA CSB-EP017457RA-B |
Recombinant Rat Poly [ADP-ribose] polymerase 1 (Parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017457HU CSB-EP017457HU CSB-BP017457HU CSB-MP017457HU CSB-EP017457HU-B |
Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP017459HU | Recombinant human Poly [ADP-ribose] polymerase 11（PARP11), partial | E.coli |
| CSB-EP017457HU1 | Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP1), partial | E.coli |
PARP1 Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017457XBE CSB-EP017457XBE CSB-BP017457XBE CSB-MP017457XBE CSB-EP017457XBE-B |
Recombinant Xenopus laevis Poly [ADP-ribose] polymerase 1 (parp1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Oryza sativa subsp. japonica (Rice)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP765912OFG CSB-EP765912OFG CSB-BP765912OFG CSB-MP765912OFG CSB-EP765912OFG-B |
Recombinant Oryza sativa subsp. japonica Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP874170DXU CSB-EP874170DXU CSB-BP874170DXU CSB-MP874170DXU CSB-EP874170DXU-B |
Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1 (PARP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP1 ELISA Kit
PARP1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E10705h | Human Poly ADP ribose polymerase,PARP ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |
