Nlrp3

NLRP3，即含pyrin结构域的NOD样受体3，别名PYRIN-containing APAF1-like protein 1。它是一种多蛋白复合体，是固有免疫系统中的重要组成部分，主要在细胞质中发挥作用。NLRP3炎性小体能够识别各种病原体相关分子模式(PAMPs)和损伤相关分子模式(DAMPs)，激活后促进半胱氨酸天冬氨酸特异性蛋白酶-1(caspase-1)的活化，进而切割前体IL-1β和IL-18成为成熟形式，引发炎症反应。NLRP3炎性小体的生物学意义在于其在调节宿主免疫反应中发挥的重要作用。它不仅参与机体对病原体的防御，还涉及多种炎症性疾病的发生发展。NLRP3炎性小体的异常激活与多种疾病相关，包括脓毒症、代谢性疾病、自身炎症性疾病等。因此，NLRP3成为了炎症性疾病治疗的潜在靶点，针对NLRP3炎性小体的抑制剂正在被广泛研究，以期开发出新的抗炎药物。

热销产品

Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial (CSB-EP822275HU2)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NLRP3 Antibody (CSB-PA015871LA01HU)

验证数据

Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA015871LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA015871LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Mouse NACHT, LRR and PYD domains-containing protein 3(NLRP3) ELISA kit (CSB-EL015871MO)

验证数据

货号：CSB-EL015871MO

规格：96T/48T

灵敏度：1.56 pg/mL

检测范围：6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Nlrp3 Antibody

Nlrp3 Protein

Nlrp3 ELISA Kit

Nlrp3 Antibodies

Nlrp3 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA005618	NLRP3 Antibody	Human	WB, ELISA
CSB-PA084492	NLRP3 Antibody	Human	ELISA,IHC
CSB-PA993403	NLRP3 Antibody	Human	ELISA,WB
CSB-PA209407	NLRP3 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA015871LA01HU	NLRP3 Antibody	Human	ELISA, IHC, IF
CSB-PA015871LB01HU	NLRP3 Antibody, HRP conjugated	Human	ELISA
CSB-PA015871LC01HU	NLRP3 Antibody, FITC conjugated	Human
CSB-PA015871LD01HU	NLRP3 Antibody, Biotin conjugated	Human	ELISA

Nlrp3 for Mus musculus (Mouse)

产品货号	产品名称	种属反应性	应用类型
CSB-PA823181LA01MO	Nlrp3 Antibody	Mouse	ELISA, IF
CSB-PA823181LB01MO	Nlrp3 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA823181LC01MO	Nlrp3 Antibody, FITC conjugated	Mouse
CSB-PA823181LD01MO	Nlrp3 Antibody, Biotin conjugated	Mouse	ELISA

Nlrp3 Proteins

Nlrp3 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP015871BO CSB-EP015871BO CSB-BP015871BO CSB-MP015871BO CSB-EP015871BO-B	Recombinant Bovine NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Nlrp3 Proteins for Macaca mulatta (Rhesus macaque)

产品货号	产品名称	来源
CSB-YP015871MOW CSB-EP015871MOW CSB-BP015871MOW CSB-MP015871MOW CSB-EP015871MOW-B	Recombinant Macaca mulatta (Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Nlrp3 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP822275HU CSB-EP822275HU CSB-BP822275HU CSB-MP822275HU CSB-EP822275HU-B	Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP822275HU1	Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial	E.coli
CSB-EP822275HU3	Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial	E.coli
CSB-EP822275HU2	Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial	E.coli
CSB-EP822275HU2a2	Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial	E.coli

Nlrp3 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP823181MO CSB-BP823181MO CSB-MP823181MO CSB-EP823181MO-B	Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3 (Nlrp3), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP823181MO	Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3 (Nlrp3), partial	E.coli

Nlrp3 ELISA Kit

Nlrp3 ELISA Kit for Homo sapiens (Human)

产品货号	产品名称	样本类型	灵敏度
CSB-E15885h	Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3/C1orf7/CIAS1/NALP3/PYPAF1) ELISA kit	serum, plasma, tissue homogenates	0.039 ng/ml