MLST8
MLST8，即哺乳动物雷帕霉素靶蛋白(mTOR)相关蛋白LST8，别名包括G蛋白β亚基样、GbetaL、GBL、Lst8、Pop3。它是一种在细胞内广泛表达的蛋白质，最高水平在骨骼肌、心脏和肾脏中。MLST8是mTORC1和mTORC2复合体的共有组成成分，对细胞生长和存活响应营养和激素信号的调节起着关键作用。MLST8的作用机制涉及到它在mTOR复合体中的功能。在mTORC1复合体中，MLST8与mTOR直接相互作用，增强其激酶活性，参与调节蛋白质合成、细胞生长和自噬等过程。在mTORC2复合体中，MLST8同样发挥重要作用，mTORC2对Rapamycin不敏感，参与胰岛素-PI3K信号通路的响应并调控细胞增殖。此外，MLST8还参与冠状病毒复制的调控，通过mTORC1信号通路影响病毒复制，敲除mLST8可以抑制mTORC1信号通路，进而激活自噬，抑制冠状病毒的复制。
热销产品
MLST8 Antibody (CSB-PA863130LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA863130LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA863130LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MLST8 Antibodies
MLST8 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA863130LA01HU | MLST8 Antibody | Human | ELISA, IHC, IF |
| CSB-PA863130LB01HU | MLST8 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA863130LC01HU | MLST8 Antibody, FITC conjugated | Human | |
| CSB-PA863130LD01HU | MLST8 Antibody, Biotin conjugated | Human | ELISA |
MLST8 Proteins
MLST8 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP613776BO CSB-EP613776BO CSB-BP613776BO CSB-MP613776BO CSB-EP613776BO-B |
Recombinant Bovine Target of rapamycin complex subunit LST8 (MLST8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP686297XBF CSB-EP686297XBF CSB-BP686297XBF CSB-MP686297XBF CSB-EP686297XBF-B |
Recombinant Xenopus tropicalis Target of rapamycin complex subunit lst8 (mlst8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP764762XBE CSB-EP764762XBE CSB-BP764762XBE CSB-MP764762XBE CSB-EP764762XBE-B |
Recombinant Xenopus laevis Target of rapamycin complex subunit lst8 (mlst8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP770424DIL CSB-EP770424DIL CSB-BP770424DIL CSB-MP770424DIL CSB-EP770424DIL-B |
Recombinant Danio rerio Target of rapamycin complex subunit lst8 (mlst8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP863130HU CSB-EP863130HU CSB-BP863130HU CSB-MP863130HU CSB-EP863130HU-B |
Recombinant Human Target of rapamycin complex subunit LST8 (MLST8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MLST8 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP863590MO CSB-EP863590MO CSB-BP863590MO CSB-MP863590MO CSB-EP863590MO-B |
Recombinant Mouse Target of rapamycin complex subunit LST8 (Mlst8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
